CORE B: PILOT CORES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这个俄克拉荷马州医学研究基金会（OMRF）COBRE有一个 近十年的成功鉴定和支持历史 试点项目，导致额外的联邦资金和科学 我们的成功者事实上，我们的前五个试点项目导致 独立，R 01资助4名研究人员，所有5名研究人员都有 充满活力的研究事业，现在近9年后（四年 俄克拉荷马州和一个领导免疫学计划在德国）。 对试点项目的额外支持导致（平均）4 每个项目的手稿，有许多高影响力的论文， 邀请在国家/国际会议上介绍其工作 会议.此外，我们之前的许多COBRE试点项目都 导致COBRE调查人员之间的新合作， 还有俄克拉荷马州外的地方这些相互作用导致了 在高影响力期刊上的合作手稿，新的科学 指导和跨实验室的技术转让。一个非常 最近的成功合作使两个OMRF COBRE 研究人员，这导致了共同PI R21 NIAID资助的赠款。 俄克拉荷马州继续有许多优秀的年轻人 研究人员与新颖的项目想法，这是成熟的最低限度 具有巨大潜在回报的投资。就凭一封邮件 公告，我们有17个潜在的试点项目的反应， 12名来自符合COBRE资格的初级研究者，其中10名 以前从未收到过COBRE的资金。所有这些 建议项目至少使用2个（和许多4个）拟议的 在这个应用程序中的科学核心。 我们的试点项目选择过程需要一个开放的 竞赛（通知初级科学家，导师， 科长和方案负责人），申请由 我们经验丰富的内部咨询委员会（与 超过100年的NIH资助）来对申请进行排名。排名 然后由我们的外部顾问审查申请 委员会，并在资源允许的情况下资助顶级项目。 所有申请人（无论是否获得资助）都将获得 对申请提出书面意见，并进行后审查 与IAC的至少一名成员进行指导会议，以帮助 改进今后提交的申请，并建议 其他融资机会。所有试点项目的接受者将 与指定的指导人员一起展示并讨论他们的进展情况 团队，并提出和讨论结果/未来的方向 在IAC和年度EAC审查中。试点项目的核心是 还通过正式的评估计划进行评估和改进 在行政核心中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This Oklahoma Medical Research Foundation (OMRF) COBRE has a nearly ten year history of successfully identifying and supporting Pilot Projects which lead to additional federal funding and scientific success of our recipients. Indeed, our first five Pilot Projects led to independent, R01 funding of 4 investigators, and all five have vibrant research careers now nearly 9 years later (four in Oklahoma and one leading an Immunology program in Germany). Additional support of Pilot Projects has led to (on average) 4 manuscripts per project, with many high impact papers and invitations to present their work at national/international meetings. In addition, many of our prior COBRE Pilot Projects have led to new collaborations between COBRE investigators within and outside Oklahoma. These interactions have led to collaborative manuscripts in high-impact journals, new scientific directions and transfer of technology across laboratories. A very recent successful collaboration partnered two OMRF COBRE investigators, which led to a co-PI R21 NIAID funded grant. Oklahoma continues to have many outstanding junior investigators with novel project ideas which are ripe for minimal investments with large potential returns. With just one e-mail announcement, we had responses for 17 potential Pilot Projects, twelve from junior COBRE-eligible investigators with ten of these never having received COBRE funds previously. All of these projects proposed to use at least 2 (and many 4) of the proposed scientific cores in this application. Our Pilot Project selection process entails an open competition (with notifications to junior scientists, mentors, section chiefs and program heads), with applications reviewed by our experienced Internal Advisory Committee (collectively with over 100 years of NIH funding) to rank applications. Ranked applications are then reviewed by our External Advisory Committee, and the top projects are funded as resources allow. All applicants (whether or not they receive funding) receive written comments about the application and have a post-review mentoring session with at least one member of the IAC to help improve the applications for future submissions and to suggest alternative funding opportunities. All Pilot Project recipients will present and discuss their progress with an assigned mentoring team, as well as present and discuss results/future directions with the IAC and at the annual EAC review. The Pilot Project Core is also evaluated and improved through a formal evaluation plan outlined in the Administrative Core.