Zebrafish International Resource Center

描述（由申请人提供）：斑马鱼是研究脊椎动物发育、生理、行为、遗传和疾病的首选生物。强大的技术可以有效地产生和恢复斑马鱼突变，影响调节发育模式、器官发生、生理和行为的基因。近年来的研究进展使研究转基因斑马鱼和反义寡核苷酸的基因功能变得容易。这些基因中的许多（如果不是大多数的话）功能在脊椎动物群体中是保守的。因此，对斑马鱼突变的分析提供了对包括人类在内的其他脊椎动物基因功能的见解。

DESCRIPTION (provided by applicant): Zebrafish is a premiere organism to study vertebrate development, physiology, behavior, genetics and disease. Powerful techniques allow efficient generation and recovery of zebrafish mutations affecting genes that regulate developmental patterning, organogenesis, physiology and behavior. Recent advances make it easy to study gene function in transgenic zebrafish and with antisense oligonucleotides. The functions of many, if not most, of these genes are conserved among vertebrate groups. Thus, analysis of zebrafish mutations provides insights into gene function in other vertebrates, including humans. The Zebrafish International Resource Center has been established as a repository that provides animals, materials and services to the research community. This proposal seeks continued funding 1) to provide a centralized repository for zebrafish genetic stocks and research materials; 2) to provide consultation and pathology services; and 3) to develop improved zebrafish husbandry methods. These materials, services and information will be made widely available to the research community.