Science in a Culture of Mentoring

俄克拉荷马州医学研究基金会的十年COBRE，“指导文化中的科学”（RR 15577）在为我们州的免疫学研究增长提供基础方面具有变革性。该COBRE提供了指导和支持，以启动12个独立的研究事业，基础设施导致了10个“非NCRR NIH研究所”计划或中心赠款，这是该资金的直接结果。OMRF和俄克拉荷马州现在可以合法地声称自己是美国免疫学的“中心”。现在，16名符合COBRE资格的调查人员提出了由指导和关键核心支持支持的项目。我们发现，指导和核心支持是我们成功的基础。人单克隆抗体（hmAb）核心生长于COBRE支持的科学观察（Nature 2008），其允许在接种后快速产生hmAb。随着超过300 hmAbs已经生产和许多项目的等待，这个核心是准备提供独特的研究工具，应该让我们的COBRE研究人员取得重大进展。血清分析物和生物标志物核心扩展了OMRF在人类自身抗体检测、细胞因子/趋化因子测量、表位定位和血清分析物开发方面的优势。它将提供对质量控制数据的集中生成的访问，以协助自身免疫，基因-环境相互作用和人类免疫反应的项目。免疫表型核心应用新的全血多参数检测详细的B细胞亚群，T细胞和其他细胞类型。该核心为许多基于免疫学的项目中的复杂人类疾病问题提供集中的SOP，测试试剂和实验设计。最后，临床核心为COBRE研究者提供患者/对照识别、招募、表型表征和人类受试者培训，所有17个拟议的试点项目都要求使用该核心。试点项目核心将通过为期一年的试点项目，确定、支持和指导符合COBRE资格的年轻科学家。在前几年中，这一周期收到了17份申请，产量极高。我们认为这些试点基金是我们在俄克拉荷马州免疫学重点的未来计划的基础。行政核心将为16名符合COBRE条件的年轻科学家提供指导团队和行政支持，实施和扩大多学科丰富计划，支持俄克拉荷马州调查人员之间的合作，评估和管理试点项目的有效性。我们相信，有了这些额外的资金，OMRF和俄克拉荷马州可以有一个杰出的免疫学卓越中心。

The Oklahoma Medical Research Foundation's ten-year COBRE, "Science in a Culture of Mentoring (RR15577) has been transformative in providing the foundation for growth in Immunology research in our state. This COBRE provided mentoring and support to launch 12 independent research careers and the infrastructure has led to 10 "non NCRR NIH institutes" program or center grants as a direct result of this funding. OMRF and Oklahoma can now legitimately claim to be a "Center" for Immunology in the United States. Now, 16 COBRE eligible investigators present projects to be supported by mentoring and critical Core support. We have found that Mentoring and Core support is fundamental to our success. The Human Monoclonal Antibody (hmAb) Core grows out of COBRE supported scientific observations {Nature 2008), which allow rapid production of hmAbs after vaccination. With over 300 hmAbs already produced and many projects waiting, this Core is poised to provide unique research tools that should allow our COBRE Investigators to make major advances. The Serum Analyte and Biomarker Core expands on OMRF's strengths in human autoantibody detection, cytokine/chemokine measurements, epitope mapping and serum analyte development. It will provide access to the centralized generation of quality controlled data to assist projects in autoimmunity, gene-environment interactions, and human immune responses. The Immunophenotyping Core applies new whole blood multiparameter testing of detailed subsets of B cells, T cells, and other cell types. This Core provides centralized SOPs, tested reagents and experimental designs for complex human disease questions in many immunology-based projects. Finally, the Clinical Core provides patient/control identification, recruitment, phenotype characterization and human subjects training to COBRE investigators, with all 17 proposed pilot projects requesting use of this Core. The Pilot Project Core will identify, support and mentor COBRE eligible junior scientists through one-year pilot projects. Extremely productive in prior years, 17 applications were received for this cycle. We view these pilot funds as fundamental to our plans for the future of our Immunology focus in Oklahoma. The Administrative Core will provide mentoring teams and administrative support to 16 COBRE eligible junior scientists, implement and expand multidisciplinary enrichment programs, support collaborations between Oklahoma investigators, evaluate and manage the effectiveness of pilot projects. We are confident that with these additional funds OMRF and Oklahoma can have an outstanding Center of Immunology Excellence.