CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages

描述（由申请人提供）： 摘要 PI：STEWART，大卫J. 项目：1 R13 AI 091053 -01题目：CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages登录号：3254930 ================== 注意事项：本摘要摘自应用程序，未经SRA验证。当应用程序扫描过程出现问题时，提取的文本可能不正确或不完整。 ================== 2010年8月24日至28日，冷泉港细菌和噬菌体分子遗传学实验室会议项目摘要细菌和噬菌体分子遗传学会议，传统上在冷泉港举行，现在在麦迪逊的威斯康星州大学和冷泉港实验室轮流举行，是展示原核分子遗传学新成果的中心论坛。大约有200-400名与会者代表世界各地的实验室参加，大多数人都发表了简短的演讲或海报。它的广泛性使其成为这个科学专业化时代信息交流的一个重要焦点。涵盖的主题包括细菌复制，重组，修复，转座，转录，基因表达控制，翻译，信号传导，热休克，蛋白质折叠和分泌，应激反应，细胞发育和分裂以及发病机制的基础工作。近年来，已作出努力，包括新兴领域，如基因组学和宏基因组学，社会微生物学，分子生态学，结构生物学和系统分析。对于许多研究生和博士后研究员来说，这是他们有机会发言的第一次大型会议。由于其高度互动的性质，会议为这些年轻科学家提供了一个重要的机会，让他们与他们从文献中认识的资深科学家会面和交谈。鉴于出席会议的学生人数众多，所涉主题多样，每次会议都邀请知名科学家主持。这加强了会议，因为每位主席都作了简短的介绍，其中他或她总结了将要讨论的领域的一些关键方面，并为会谈将要解决的主要问题提供了一个概念框架。作为一个额外的好处，在会议公告中公布明智选择的主席和会议主题，鼓励提交令人兴奋的新领域的摘要，并刺激更多的支持者出席会议。2010年8月24日至28日，冷泉港实验室关于芽孢杆菌和噬菌体分子遗传学的会议发言单细胞微生物被称为细菌，可以在地球上几乎所有的生态系统中找到，从极端环境到人类肠道。人类已经进化出强大的免疫力，可以与许多细菌共存，甚至可以在从奶酪制作到生物技术的过程中使用细菌，但在不利条件下，细菌会导致许多重要的传染病，如结核病，霍乱或梅毒。就像植物和动物有病毒一样，细菌也可以被噬菌体感染，从而改变它们的新陈代谢和生物化学。几十年来，噬菌体一直被科学家用作精致的遗传工具，以探测细菌分子机制的许多基本方面。这项工作帮助我们了解细菌如何控制它们的生命周期，细胞如何繁殖和分裂，以及它们如何在环境中生存和感知环境。研究现在正在从单个细菌细胞如何发挥作用转向微生物菌落如何合作和生存，以及这些菌落如何适应环境的变化，在土壤中，海底或动物或人类宿主中的各种小生境中。这次国际会议将为从事相关主题的科学家提供一个论坛，分享他们的最新发现，并将汇集该领域的领先专家。

DESCRIPTION (provided by applicant): Abstract PI: STEWART, DAVID J. Project: 1R13AI091053-01 Title: CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages Accession Number: 3254930 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM APPLICATION AND HAS NOT BEEN PROOFED BY AN SRA.WHEN THERE ARE PROBLEMS WITH THE APPLICATION SCANNING PROCESS, THE EXTRACTED TEXT MAY BE INCORRECT OR INCOMPLETE. ================== COLD SPRING HARBOR LABORATORY CONFERENCE ON THE MOLECULAR GENETICS OF BACTERIA AND PHAGES AUGUST 24 - 28, 2010 PROJECT SUMMARY The Molecular Genetics of Bacteria and Phages Conference, traditionally held at Cold Spring Harbor and now being held in alternate years at the University of Wisconsin in Madison and at the Cold Spring Harbor Laboratory, is a central forum for the presentation of new results in prokaryotic molecular genetics. On the order of 200-400 participants attend, representing laboratories throughout the world, and most present either short talks or posters. Its breadth makes it an important focus for the exchange of information in this era of scientific specialization. Topics covered include fundamental work on bacterial replication, recombination, repair, transposition, transcription, control of gene expression, translation, signaling, heat shock, protein folding and secretion, stress response, cell development and division, and pathogenesis. In recent years, efforts have been made to include emerging areas such as genomics and metagenomics, sociomicrobiology, molecular ecology, structural biology and systems analysis. For many graduate students and postdoctoral fellows, this is the first large meeting at which they have an opportunity to speak. Due to its highly interactive nature, the meeting provides an important opportunity for these young scientists to meet and talk to the senior scientists they know from the literature. In response to the large numbers of students who attend the meeting and the diversity of topics covered, established and distinguished scientists are invited to chair each session. This strengthens the meeting because each chairperson gives a short introduction in which he or she summarizes some of the key facets of the field to be covered and provides a conceptual framework for the major questions that the talks will address. As an additional benefit, publicizing the judiciously chosen chairpeople and session topics in announcements of the meeting encourages the submission of abstracts in exciting new areas and stimulates attendance by a larger constituency. COLD SPRING HARBOR LABORATORY CONFERENCE ON THE MOLECULAR GENETICS OF BACTERIA AND PHAGES AUGUST 24 - 28, 2010 LAY STATEMENT The unicellular microorganisms known as bacteria can be found in almost all ecosystems on the planet, from extreme environments to the human gut. Humans have evolved robust immunity to live alongside many bacteria, and indeed to use bacteria in processes from cheese-making to biotechnology, but under adverse conditions, bacteria are responsible for many important infectious diseases such as tuberculosis, cholera or syphilis. Much as plants and animals have viruses, so bacteria can be infected by bacteriophages that alter their metabolism and biochemistry. Phages have been used by scientists for many decades as exquisite genetic tools to probe many fundamental aspects of the molecular machinery at work in bacteria. This work has helped us to understand how bacteria control their life cycle, how cells reproduce and divide, and how they survive in and sense their environment. Research is now shifting from how individual bacterial cells function to how colonies of microorganisms collaborate and survive, and how these colonies adapt to changes in their environment, in niches as varied as in the soil, under the sea, or in an animal or human host. This international conference will provide a forum for scientists working on related topics to share their latest discoveries and will bring together the leading experts in the field.