12th International Symposium on Human Chlamydial Infections

描述(由申请者提供)：为第十二届衣原体感染国际研讨会申请资金支持。沙眼衣原体感染是性传播疾病最常见的细菌原因，通常会导致妇女和新生儿的严重病理。它还增加了感染艾滋病毒的风险。沙眼衣原体也是美国疾病控制和预防中心报告的最常见的感染。这些微生物也是沙眼的原因，沙眼是世界上可预防的失明的主要原因。肺炎衣原体被认为是一种非常常见的呼吸道病原体，肺炎衣原体与慢性呼吸道疾病和冠状动脉疾病的相关性增加了了解这些感染的必要性。随着诊断分子技术的进步，扩大的衣原体疾病临床谱系的特征得到了便利。与此同时，在阐明衣原体生物与其哺乳动物宿主细胞之间复杂的相互作用以及免疫和发病的分子机制方面取得了令人兴奋的进展。这一领域的进展重新点燃了人们对衣原体疫苗的兴趣。此外，从最近沙眼衣原体和肺炎衣原体基因组测序中推断出的信息正在迅速为基础衣原体生物学提供新的见解。这次会议是该领域研究人员交流最高质量研究信息的最重要的聚会。鉴于最近衣原体研究的爆炸性增长，特别需要将于2010年6月举行的第十二届人类衣原体感染国际研讨会。这一会议传统上每四年举行一次。可以预期，它将为制定未来几年的衣原体研究议程提供独特的动力。佩奇首席研究员/项目主任(最后、第一、中间)：沙赫特，朱利叶斯，博士项目简介沙眼衣原体是世界上可预防的失明的主要原因，也是我们最常见的性传播细菌病原体，对受影响的男性、女性和新生儿造成严重后果。肺炎衣原体是一种非常常见的呼吸道病原体，与慢性呼吸系统疾病和冠状动脉疾病密切相关。随着最近在诊断和基因组学方面的进展，很可能即将取得重要进展，分子生物学技术已经并将继续帮助进一步确定衣原体疾病的临床特征。虽然这些生物的遗传系统还没有开发出来，但最近在衣原体的免疫生物学、细胞生物学和生理学方面仍有令人兴奋的发现。这次会议是在几个衣原体基因组测序完成并在研究发现中挖掘这些信息之后举行的。随着最近关于这些生物体的信息的爆炸性增长，现在是就这一主题举行一系列定期国际会议的时候了。以往这些会议的成功证明了这一场所在交流信息和比较不同国家的成果方面的价值。这些会议继续为新的研究提供动力，并为衣原体研究人员之间分享研究成果提供了一个独特的综合场所。这次会议的一个重要而独特的特点是将从遗传学到临床试验的跨学科研究人员的科学交流聚集在一起。

DESCRIPTION (provided by applicant): Financial support is requested for the XIIth International Symposium on Human Chlamydial Infection. Chlamydia trachomatis infections are the most common bacterial cause of sexually transmitted diseases often resulting in severe pathology in women and newborns. It also increases the risk of HIV infection. C. trachomatis is also the most common infection reported to the Centers for Disease Control and Prevention in the United States. These organisms are also the cause of trachoma, the leading cause of preventable blindness in the world. C. pneumoniae is recognized as a very common respiratory pathogen and the association of C. pneumoniae with chronic respiratory diseases and coronary artery diseases increases the need for understanding these infections. Characterization of the expanded clinical spectrum of chlamydial diseases has been facilitated by advances in molecular techniques for diagnosis. This has been complemented by exciting advances in elucidating the sophisticated interplay between chlamydial organisms and their mammalian host cells and the molecular mechanisms of immunity and pathogenesis. Interest in chlamydial vaccines has been rekindled by advances in this area. Additionally, the information inferred from the recent sequencing of the C. trachomatis and the C. pneumoniae genomes is rapidly providing new insights into fundamental chlamydial biology. This meeting represents the most important gathering for researchers in the field to exchange the highest quality research information. Given the recent explosion of research on chlamydiae, the XIIth International Symposium on Human Chlamydial Infection to be held in June 2010 is particularly needed. This meeting is traditionally held only every four years. It can be expected to uniquely provide the impetus for setting the research agenda on the chlamydiae for the coming years. Page Principal Investigator/Program Director (Last, first, middle): Schachter, Julius, PhD. Project Narrative Chlamydia trachomatis is the world's leading cause of preventable blindness and our most common sexually transmitted bacterial pathogen with serious consequences to affected men, women, and newborn infants. C. pneumoniae is recognized as a very common respiratory pathogen and has been implicated in chronic respiratory disease and coronary artery disease. With recent advances in diagnosis and genomics, it is likely that important advances are imminent and techniques in molecular biology have aided and will continue to help in further characterizing the clinical spectrum of chlamydial diseases. Although no genetic system for these organisms has yet been developed, there have still been recent exciting findings on immunobiology, cell biology, and physiology of chlamydiae. This meeting follows the completion of the sequencing of several chlamydial genomes and the mining of this information in research discovery. With the recent explosion of information on these organisms, the time is right for another in a series of periodic international meetings on the subject. Previous success of these meetings has attested to the value of this venue for exchanging information and comparison of results in different countries. These meetings have continued to provide impetus for new research and represent a singular comprehensive venue for sharing of research findings among and between Chlamydia researchers. One of the important and unique characteristics of this meeting is bringing together a scientific exchange among researchers across disciplines from genetics to clinical trials.