MOVEMENT DISORDERS AND EYE MOVEMENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的：了解高级加工或认知在随意运动控制中的作用。 由于自愿行动的执行通常涉及目标选择、学习、记忆、计划和期望等过程，因此运动系统非常适合研究这些过程。我们研究了导致眼睛运动的神经过程，特别是那些导致视线快速变化的眼球运动-扫视。 我们有一个多技术的方法来研究这些过程。首先，我们记录单个神经元的电活动，同时受试者执行旨在挖掘认知过程的眼动任务。第二，我们激活或激活大脑的特定区域，以产生行为或干扰正在进行的行为和神经处理。最后，由于某些大脑区域的损伤会产生严重的临床疾病，如帕金森病和亨廷顿病，我们研究了健康和患病人类受试者的眼球运动，以进一步了解这些结构在认知和产生这些疾病的衰弱效应中所起的作用。这项研究使用WNPRC动物服务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To understand how higher order processes or cognition contribute to the control of voluntary movement. Because the execution of voluntary actions usually involves processes such as target selection, learning, memory, planning and expectation, motor systems are well suited for study of these processes. We investigate neuronal processes leading up to the execution of movements of the eyes, in particular, those eye movements that lead to rapid changes in the line of sight - saccades. We have a multi-technique approach to the study of these processes. First, we record electrical activity of single neurons while the subjects perform eye movement tasks designed to tap into cognitive processes. Second, we activate or inactivate particular regions of the brain to produce behaviors or interfere with ongoing behaviors and neural processing. Finally, because damage to certain brain regions produces profound clinical disorders such as Parkinson's disease and Huntington's disease, we study eye movements of both healthy and diseased human subjects to further our understanding of the role these structures play in both cognition and in producing the debilitating effects of these disorders. This research used WNPRC Animal Services.