INHALATION EXPOSURE FACILITY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 位于中国人民大学的吸入暴露设施是现有的大学校园中最大的设施之一。它允许使用非人类灵长类动物进行与人类健康相关的独特肺部研究机会。有能力在体内或体外暴露于精确表征和控制的气体和气雾剂大气中。对于空气污染研究对健康的影响，用于暴露研究的测试对象范围可以包括动物、分离和灌流的肺、气管外植体以及人或猴子的肺细胞培养。这使得可以采用综合的、比较的方法来确定呼吸系统损伤和修复的机制。肺功能实验室为婴儿和成年非人类灵长类动物提供全面的测试。 提供的服务： +特别曝光 +臭氧产生和监测 +气溶胶产生和分析 +NOx的产生和监测 +过敏原产生和分析 +过滤空气暴露量 +ETS生成和分析 肺功能检测实验室 +基准气道阻力测试 +航空公司响应性测试 +过敏原反应性测试 +静态肺力学测试 +后期变应原反应性测试 该设施继续按照研究项目的要求，提供稳定的、具有良好特性的暴露于空气污染物、过敏原、治疗剂、气雾剂和其他测试环境中。作为核心服务提供者，该设施在本报告所述期间支持了18个研究项目，约有27名主要调查人员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Inhalation Exposure Facility located at the CNPRC is one of the largest in existence on a university campus. It permits unique human health-related pulmonary research opportunities using nonhuman primates. Capabilities exist for in vivo or in vitro exposure to precisely characterized and controlled atmospheres of gases and aerosols. For health effects of air pollution research, the range of test subjects used for exposure studies can include animals, isolated and perfused lungs, tracheal explants and human or monkey lung cell cultures. This permits an integrated, comparative approach to defining mechanisms of respiratory system injury and repair. The pulmonary function laboratory offers a comprehensive array of testing for infant through adult nonhuman primates. Services Offered: + Special Exposures + Ozone Generation and Monitoring + Aerosol Generation and Analysis + NOx Generation and Monitoring + Allergen Generation and Analysis + Filtered Air Exposure + ETS Generation and Analysis Pulmonary Function Testing Laboratory + Baseline Airway Resistance Testing + Airway Responsiveness Testing + Allergen Responsiveness Testing + Static Lung Mechanics Testing + Late Phase Allergen Responsiveness Testing This facility continued to provide stable, well characterized exposures to air pollutants, allergens, therapeutic agents, aerosols and other test atmospheres as required by the research projects. As a core service provider, the facility supported 18 research projects during the reporting period with some 27 major investigators.