EFFECT OF RELOCATION ON NIGHTTIME ACTIVITY AND STRESS RESPONSES IN MACAQUES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 SIB是一个严重的人类健康问题，在青少年和年轻人中呈上升趋势。在正常饲养的成年雄性恒河猴中，有一小部分会自发地患上SIB。在这个子项目中，我们研究了搬迁应激对患有和不患有SIB的恒河猴的行为和下丘脑-垂体-肾上腺功能的短期和长期影响。多年来，这些猴子一直被关在一栋旧建筑里，从地板到天花板的围栏里。当这座建筑被重新检查并计划拆除时，猴子们被转移到了一座新建筑。由于这些猴子将被安置在不同笼子安排和不熟悉的动物的房间里，搬家预计会有压力。在白天和晚上进行行为评估，并在行动前、行动后立即和行动后一年收集血浆、唾液和头发样本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SIB is a significant human health problem which is on the rise among teenagers and young adults. A small percentage of normally reared, adult male rhesus monkeys spontaneously develop SIB. In this subproject, we examined the short- and long-term effects of a relocation stress on behavior and hypothalamic-pituitary-adrenal function in rhesus monkeys with and without SIB. The monkeys had been housed for many years in floor-to-ceiling pens in an old building. When the building was reexamined and slated for demolition, the monkeys were moved to a new building. Because the monkeys were to be housed in rooms with different caging arrangements and unfamiliar animals, the move was expected to be stressful. Behavioral assessments were conducted during daylight and evening hours, and samples of plasma, saliva, and hair were collected before, immediately after and 1 year following the move.