TOPICAL MICROBICIDE AGAINST SIV AND CHLAMYDIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：测试一种潜在的杀菌剂预防艾滋病病毒传播给妇女的效果。迫切需要这样一种有效的媒介，以应对全球妇女艾滋病毒新感染人数普遍上升的现象。 这项建议在体内测试了单月桂酸甘油对防止猴免疫缺陷病毒经阴道传播到恒河猴的有效性。恒河猴是一种高度相关的非人类灵长类动物，HIV的性黏膜传播模型。我们发现，单月桂酸甘油不会改变恒河猴(Macaca Mulatta)的阴道乳杆菌，并且长期使用是安全的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To test the efficacy of a potential microbicidal agent to prevent transmission of HIV to women. Such an effective agent is urgently needed to combat the predominant rise globally of new HIV infections in women. This proposal tested in vivo the efficacy of glycerol monolaurate to prevent intravaginal transmission of simian immunodeficiency virus to rhesus macaques, a highly relevant nonhuman primate model of sexual mucosal transmission of HIV. We found that glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginallactobacilli and is safe for chronic use.