EXPANDING WNPRC RESOURCES FOR AIDS-RELATED RESEARCH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：威斯康星州国家灵长类动物研究中心(WNPRC)的SIV计划的主要目标是了解有效的抗免疫缺陷病毒免疫反应的属性，开发新型艾滋病疫苗，并扩展HIV动物模型，以包括毛里求斯食蟹猴(Macaca Fasularis)独特的遗传属性。 WNPRC正在经历动物住所的严重短缺，这将直接影响艾滋病研究的持续进展。我们目前的SIV住房设施接近饱和，将不足以满足我们的长期住房需求。住房不足很快就会成为设计新研究时的一个限制因素。我们目前有120只感染SIV的猕猴的空间，正在进行积极研究的动物占据了其中的82个空间。保守估计，利用已经到位的资金，2008年需要额外增加的动物数量为142只。这一估计不包括大型研究，在这些研究中，悬而未决的资金可能使这一数字远远超过250只动物。这项20国集团赠款提案的主要目标是将毗邻现有SIV住宅区的现有标本储存区翻新为三个新的动物住房。还要求提供资金，为这些新的动物室配备足够的笼子和自动浇水系统。完成这一翻修将为SIV项目在WNPRC的扩展和调查人员继续他们的开创性研究提供必要的关键空间。规划阶段已经完成，目前正在进行翻修。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The primary objectives of the SIV program at the Wisconsin National Primate Research Center (WNPRC) are to understand the attributes of effective anti-immunodeficiency virus immune responses, develop novel AIDS vaccines, and expand the HIV animal model to include the unique genetic attributes of cynomolgus macaques (Macaca fasicularis) from Mauritius. The WNPRC is experiencing a critical shortage of animal housing which will directly affect continued advances in AIDS research. Our current SIV housing facility is near capacity and will be insufficient for our long-term housing needs. Inadequate housing will soon become a limiting factor when designing new studies. We currently have space for 120 SIV-infected macaques, and animals on active studies occupy 82 of those spaces. A conservative estimate of the number of additional animals needed in 2008 using funding already in place is 142. This estimate does not include large studies where pending funding could push this number well beyond 250 animals. The primary goal of this G20 grant proposal is to renovate an existing specimen storage area, which is adjacent to the existing SIV housing area, into three new animal housing rooms. Funding is also requested for sufficient caging and an automatic watering system to equip these new animal rooms. Completing this renovation will provide the critical space necessary for the SIV program to expand at the WNPRC and for the investigators to continue their ground-breaking research. The planning phase has been completed and renovation is now underway.