Genomic Psychiatry Cohort

描述(由申请人提供)：双相情感障碍和精神分裂症的基因组分析：对美国和全球范围内的大型队列的研究“。南加州大学(南加州大学基因组精神病学中心)、马萨诸塞州总医院(MGH)-布罗德研究所(斯坦利中心)和全国学术医学中心网络创建了基因组精神病学队列(GPC)。这项应用寻求通过NIMH资料库扩大目前可用于现场的资源，增加来自相同地理区域的10,000名特征良好的精神分裂症患者和10,000名对照的样本。此外，将对5000名患者和5000名对照进行全基因组关联研究，以确定精神分裂症的遗传风险。来自20,000名受试者的血液/DNA将与来自GWA研究的临床和表型数据以及全基因组SNP数据一起存储在NIMH储存库中。此外，我们计划对第二个10,000名受试者进行基因分型，以获得祖先信息标记和候选基因的复制。我们的目的是确定和招募大量精神分裂症患者的临床队列，并对其进行前瞻性跟踪，以便持续仔细地评估表型和未来嵌套病例对照研究的可能性。我们还将为特定遗传结果的快速复制和未来可能的大规模高通量基因组研究提供生物信息学和分子基础设施。南加州大学(USC)及其合作伙伴创建了基因组精神病学队列，以研究在其医疗系统中接受治疗的大量精神分裂症患者。该队列的成员是长期患者，他们同意参与与了解这些疾病的遗传和环境风险相关的研究。这种类型的人口研究对于了解风险、帮助开发治疗方法和了解这种重大疾病的预防至关重要。

DESCRIPTION (provided by applicant): Genomic Parsing of Bipolar Disorder and Schizophrenia: Studies of Large Cohorts in the U.S. and Across the Globe". The University of Southern California (USC Center for Genomic Psychiatry), the Massachusetts General Hospital (MGH)-Broad Institute (Stanley Center) and a nation-wide network of academic medical centers have created the Genomic Psychiatry Cohort (GPC). This application seeks to expand the resources currently available to the field, through the NIMH Repository, with an additional sample of 10,000 well-characterized patients with schizophrenia and 10,000 controls from the same geographic regions. Further, a genome-wide association study of 5,000 patients and 5,000 controls will be performed to identify genetic risks for schizophrenia. The blood/DNA from the 20,000 subjects will be deposited in the NIMH repository, along with clinical and phenotypic data, and genome wide SNP data from the GWA study. In addition, we plan to genotype the second 10,000 subjects for ancestry informative markers and replication of candidate genes. Our intent is to ascertain and recruit a large clinical cohort of patients with schizophrenia that will be prospectively followed in order to allow ongoing careful assessment of phenotype and the possibility of future nested case-control studies. We will also provide the bioinformatics and molecular infrastructure for rapid replication of specific genetic results and future potential large-scale high-throughput genomic investigations. The University of Southern California (USC) and its partners have created the Genomic Psychiatry Cohort to study very large groups of patients suffering with schizophrenia treated in their health systems. Members of the cohort are long-term patients that have agreed to participate in studies related to understanding the genetic and environmental risks for these disorders. This type of population study is critical to understanding risk, helping develop treatments, and understanding prevention of this major illness.