Molecular studies of the astrocyte reservoir of HIV-1 in the central nervous system

艾滋病毒感染大脑，导致10-20%的患者痴呆。旨在根除艾滋病毒感染的战略没有考虑到中枢神经系统感染。了解艾滋病毒在大脑中进入、感染和复制的方式，对于开发预防大脑感染和痴呆的药物至关重要。我们的研究表明，艾滋病毒感染大脑的机制与在血液和其他器官中观察到的机制不同。本研究旨在阐明这些机制。

HIV infects the brain causing dementia in 10-20% patients. Strategies aimed at eradicating HIV infection fail to take into account CNS infection. Understanding the way in which HIV enters, infects and replicates in the brain is pivotal in development of drugs to prevent brain infection and dementia. Our studies have shown that HIV infection of the brain involves mechanisms distinct to those observed for blood and other organs. This study seeks to clarify such mechanisms.