Hospital Medicine and Economics Centers for Education & Research for Therapeutics

描述（由申请人提供）：医院是药物、生物制品和器械的密集使用场所，对治疗结果和成本有重大影响。 在过去的十年中，医院护理已经开始了一个重大的转变，通过越来越多地使用临床信息系统和系统的方法来提高安全性和质量，以及在医院护理专业的医生，包括重症监护医生和住院医生的数量迅速增长。 在未来十年，新的基础和转化技术，如药物基因组学和临床信息学，有望为医院环境带来个性化医疗的新时代。 这使得生产和传播关于有效和具有成本效益地使用医院治疗方法的知识尤为及时和重要。 本申请的目的是请求支持建立一个治疗学教育和研究中心（CERT），该中心专注于医院医学，主要方法学重点是临床经济学。 这些在CERT资助机会公告（FOA）中被确定为高度优先领域。 此外，还将把另一个高度优先领域个性化医疗作为第二重点。 医院医学和经济学CERT的总体目标是建立一个强大的教育和研究基础设施，以生产和传播知识，提高医院使用治疗方法的有效性和成本效益，包括药物，生物制品和设备。 医院医学和经济学CERT将设在芝加哥大学（UC），该大学在医院医学研究和临床经济学以及个性化医疗方面都具有独特的资格。 医院医学和经济学CERT还将受益于伊利诺伊大学芝加哥分校（UIC）药学院的参与，该学院已经通过发展证据告知有关有效性的决策（DECIDE）计划与UC和AHRQ在这一领域合作。 此外，医院医学和经济学CERT将受益于与Consorta，Inc的合作，Consorta，Inc是一个由500多家医院组成的全国性网络，并能够利用由UC领导的现有多中心医院医学研究小组（包括Brigham and Women's Hospital、加州大学弗朗西斯科分校、爱荷华州大学和威斯康星州大学的研究人员）。 医院医学和经济学CERT还将通过与医院医学协会的重要合作伙伴关系以及与国家意见研究中心（NORC）的联系，获得全国范围和影响力。

DESCRIPTION (Provided by the Applicant): Hospitals are the site of intensive use of drugs, biological products, and devices, with a major impact on both the outcome and cost of care. In the past decade, hospital care has begun a major transformation through the increasing use of clinical information systems and systematic approaches to improving safety and quality, and the rapid growth in the number of physicians specializing in hospital care, including intensivists and hospitalists. In the next decade, new basic and translational technologies, such as pharmacogenomics and clinical informatics, hold promise to bring a new era of personalized medicine to the hospital setting. This makes the production and dissemination of knowledge about the effective and cost-effective use of hospital therapeutics especially timely and important. The purpose of this application is to request support to establish a Center for Education and Research on Therapeutics (CERT) focused on hospital medicine with a major methodological focus on clinical economics. These are identified in the CERT Funding Opportunity Announcement (FOA) as high priority areas. In addition, there will be a secondary focus on personalized medicine, another high-priority area. The overall aim of the Hospital Medicine and Economics CERT will be to create a powerful education and research infrastructure to produce and disseminate knowledge to improve the effectiveness and cost-effectiveness of the use of therapeutics in hospitals, including drugs, biological products, and devices. The Hospital Medicine and Economics CERT will be based at the University of Chicago (UC), which has unique qualifications in both hospital medicine research and in clinical economics, as well as in personalized medicine. The Hospital Medicine and Economics CERT will also benefit from the participation of the University of Illinois-Chicago (UIC) School of Pharmacy, which already collaborates with UC and AHRQ in this area through the Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) program. In addition, the Hospital Medicine and Economics CERT will benefit from collaboration with Consorta, Inc, a national network of over 500 hospitals, and the ability to draw upon a pre-existing multicenter hospital medicine research group led by UC (including investigators at Brigham and Women's Hospital, the University of California-San Francisco, the University of Iowa, and the University of Wisconsin). The Hospital Medicine and Economics CERT will also gain national scope and impact through an important partnership with the Society of Hospital Medicine, and through affiliation with the National Opinion Research Center (NORC).