Community Clinical Oncology program Research Base

描述（由申请人提供）：儿童肿瘤学小组（COG）的使命是通过科学发现和同情心护理来治疗和预防儿童和青少年癌症。我们的愿景是通过开展治疗试验、病因学和预防研究，减轻治疗相关后遗症的负担，提高生存率，从而消除儿童和青少年癌症的个人、家庭和社会负担。该项目于2002年首次获得资助，用于继续作为治疗和癌症预防与控制社区临床肿瘤学计划（CCOP）研究基地。COG是世界上最大的儿童癌症研究组织，包括231个儿童癌症项目，其中27个隶属于CCOPs/少数民族CCOPs。COG CCOP研究基地利用COG的组织和设施，为社区儿科癌症治疗中心提供治疗，癌症生物学，癌症预防和控制协议。社区儿科医生参与COG的研究使命是一个高度优先事项。我们在当前资助期间的表现得到了有力的证明：癌症预防和控制研究的应计费用逐年显著增加;可用协议数量稳步增加; COG疾病，学科和其他科学委员会之间的互动增强，从而形成更综合的癌症控制协议概念;以及CCOP研究人员积极参与COG运营。癌症预防和控制的增加从2003年3月1日至2004年2月29日的91人增加到2004年3月1日至2005年2月28日的377人，再增加到2005年3月1日至2006年2月1日的1 195人。在2004-2005年期间，该委员会有10项公开的癌症控制协议，2005-2006年增加到18项协议。癌症预防和控制研究由COG癌症控制委员会协调，该委员会确定了以下优先领域：与治疗有关的永久性残疾;营养、肥胖/能量平衡;急性症状/治疗并发症;生命终了/姑息治疗;以及患者报告的结果。CCOP小组委员会促进儿科癌症控制研究的设计和实施，并支持CCOP成员机构和研究人员在当地和集团范围内的事务。CCOPs提供了一个重要的机制，以评估在社区环境中管理的先进治疗，并扩大了协议参与的人口基础。

DESCRIPTION (provided by applicant): The mission of the Children's Oncology Group (COG) is to cure and prevent childhood and adolescent cancer through scientific discovery and compassionate care. Our vision is to eliminate the personal, familial, and societal burden of cancer in children and adolescents by conducting, treatment trials, etiologic and prevention studies to lessen the burden of treatment-related sequelae and improve survivorship. First funded in 2002, this application is for COG to continue to serve as a Treatment and Cancer Prevention and Control Community Clinical Oncology Program (CCOP) Research Base. COG is the largest childhood cancer research organization in the world encompassing 231 pediatric cancer programs including 27 affiliated with CCOPs/Minority-Based CCOPs. The COG CCOP Research Base utilizes the organization and facilities of the COG to provide community pediatric cancer treatment centers access to treatment, cancer biology, cancer prevention and control protocols. Involvement of community-based pediatricians in the research mission of the COG is a high priority. Our performance in the current grant period has been strong evidenced by: a striking year-to-year increase in accrual to cancer prevention and control studies; steady increases in the number of available protocols; enhanced interactions between COG Disease, Discipline and other scientific committees resulting in more integrated cancer control protocol concepts; and active participation of CCOP investigators in COG operations. Cancer prevention and control accrual rose from 91 in 3/1/03-2/29/04 to 377 in 3/1/04-2/28/05 to 1,195 for the 3/1/05-2/1/06 period. In the 2004-2005 period, COG had 10 open cancer control protocols, this increased to 18 protocols in 2005-2006. Cancer prevention and control research is coordinated by the COG Cancer Control Committee which has identified the following priority areas: permanent treatment-related disabilities; nutrition, obesity/energy balance; acute symptoms/complications of treatment; end-of life/palliative care; and patient-reported outcomes. The CCOP Subcommittee promotes the design and conduct of pediatric cancer control research as well as supports CCOP member institutions and investigators in both local and Group-wide affairs. CCOPs provide an important mechanism to evaluate advanced treatments administered in community settings and broaden the population-base for protocol participation.