Translational Laboratory

项目总结(见说明)： 转化实验室共享服务(TLSS)支持马里兰大学马里兰分校和斯图尔特·格林鲍姆癌症中心(UMGCC)在临床前和临床环境下进行药物开发的研究人员。Sen/ICS包括处理人类临床试验样本，开发药效终点分析方法，在体外分析新的癌症治疗方法，以及在体内癌症模型中单独或联合评估新药物。TLSS为临床医生和基础研究人员提供支持。对于临床医生来说，TLSS处理从临床试验中产生的组织，通常扮演着临床试验人员和其他核心之间的管道角色，并在UMGCC内共享服务。在TLSS内生成处理材料的标准操作程序，并将其分发给必要的 参与管理临床试验的人员。此外，TLSS还开发了在第一阶段和L/11阶段临床试验中测试一种新化合物在人体组织中的功能活性的方法。最后，对于那些没有自己的实验室的临床医生，TLSS为临床医生提供了进行基础研究或培训住院医生或实习生进行实验室研究的机会。临床前研究人员可能会选择 当实验范围超出可用资源或超出其专业领域时，可利用TLSS服务。例如，关于活体工作，研究人员可能更喜欢使用TLSS的伞状动物使用协议(AUP)，而不是编写他们自己的AUP并通过机构动物护理和使用委员会进行处理。此外，TLSS被独特地设置为在多个 以确定疗效的范围、程度或特异性。TLSS人员与临床医生和基础研究人员会面，讨论实验设计以及预期结果和适当的对照。对于UMGCC的研究人员来说，TLSS是一个很好的资源。

PROJECT SUMMARY (See instructions): The Translational Laboratory Shared Service (TLSS) supports investigators performing drug development in the preclinical and clinical settings at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC). Sen/ices include processing of human clinical trial specimens, developing assays for pharmacodynamic endpoints, assaying novel cancer therapeutics in vitro, and evaluating novel agents aloneor in combination in in vivo cancer models. The TLSS supports both the clinician and basic investigator. For the clinician, the TLSS processes tissue generated from clinical trials, often playing the role of conduit between the clinical trialist and other cores and shared services within UMGCC. Standard operating procedures for processing the material are generated within TLSS and distributed to the necessary personnel involved in administering the clinical trial. In addition, TLSS develops assays to test the functional activity of a novel compound in human tissue from Phase I and Phase l/ll clinical trials. Last, for those clinicians without laboratories of their own, the TLSS provides the opportunity for the clinician to perform basic research or to train residents or interns in laboratory research. A preclinical investigator may choose to utilize TLSS services when the scope of an experiment exceeds the resources available or is outside his or her area of expertise. For example, regarding In vivo work, investigators may prefer to use the TLSS's umbrella animal use protocol (AUP) rather than writing an AUP of their own and processing it through the Institutional Animal Care and Use Committee. Also, TLSS is uniquely set up to screen compounds in multiple cell lines to determine the range, extent, or specificity of efficacy. TLSS personnel meet with both clinicians and basic researchers to discuss experimental designs as well as expected outcomes and appropriate controls. The TLSS is an excellent resource for researchers to use at UMGCC.