The Manhattan HIV Brain Bank

描述（由申请人提供）：曼哈顿HIV脑库（MHBB）是国家神经艾滋病组织联盟（NNTC）的成员，自1998年以来一直是神经艾滋病研究界的资源。它进行神经，神经心理学，精神病学，一般医学和尸检病理学评估的主要是艾滋病毒感染者的队列，谁同意死后器官捐赠者，为neuroAIDS和AIDS研究的目的。由于MHBB的观察性纵向研究，其组织和液体资源被密集注释，并支持对HIV相关中枢（CNS）和外周神经系统（PNS）疾病的广泛调查。在下一个周期中，MHBB将与NNTC的其他成员一起创建一个队列，用于研究CNS储库，衰老和在抗逆转录病毒治疗中持续存在的HIV相关认知障碍的发病机制。具体来说，MHBB将增加其在老年人中的代表性，以及那些在可变CD4最低点后血浆病毒载量稳定抑制的人。随着这一转变，MHBB将保持反映 纽约市流行病，包括少数民族，妇女和社会文化和医学复杂的个人的突出代表。MHBB将定期将临床和病理信息上传至中央联盟数据库，参与NNTC的所有方案定义和质量保证计划，并通过NNTC数据协调中心领导的中央流程将其信息、组织和液体分发给研究者。MHBB将继续分析其队列的行为和神经表型，以更好地了解神经艾滋病疾病如何在老龄化，人口统计学上多样化的个体中表现出来，这些个体在治疗时代的变化中生活。通过观察性研究，MHBB将更好地为神经艾滋病研究人员服务，因为仔细描绘表型将确保更好地分配研究设计的资源。此外，HIV相关CNS和PNS疾病的观察性研究将使MHBB能够更好地了解受试者特征的神经生物学相关方法，以及如何随着HIV流行病的持续发展继续修改队列。

DESCRIPTION (provided by applicant): The Manhattan HIV Brain Bank (MHBB), member of the National NeuroAIDS Tissue Consortium (NNTC), has been a resource for the neuroAIDS research community since 1998. It performs neurologic, neuropsychological, psychiatric, general medical, and autopsy pathology assessments on a cohort of predominantly HIV-infected individuals, who agree to be organ donors upon demise, for the purposes of neuroAIDS and AIDS research. As a result of MHBB's observational longitudinal study, its tissue and fluids resources are densely annotated, and support a wide range of investigations into HIV-associated central (CNS) and peripheral nervous system (PNS) disorders. In the next cycle, MHBB will participate with other members of the NNTC to create a cohort optimized for the study of CNS reservoirs, aging, and pathogenesis of HIV-associated cognitive disorders persisting in the face of antiretroviral therapy. Specifically, MHBB will increase its representatin of older individuals, and those with stably suppressed plasma viral loads following variable CD4 nadirs. With this transition, MHBB will maintain important cohort characteristics reflective of the NYC epidemic, including prominent representation of minorities, women, and socio-culturally and medically complex individuals. MHBB will regularly upload clinical and pathologic information into a central consortium database, participate in all the protocol-defining and qualit assurance programs of the NNTC, and distribute its information, tissues, and fluids to investigators through central processes led by the NNTC data coordination center. MHBB will continue to analyze the behavioral and neurologic phenotypes of its cohort, to better understand how neuroAIDS disorders manifest in aging, demographically diverse individuals living through changes in therapeutic eras. Through observational studies, MHBB will better serve neuroAIDS researchers, as careful delineation of phenotype will assure better assignment of resources to research designs. Furthermore, observational study of HIV-associated CNS and PNS disease will allow MHBB to better understand neurobiologically relevant methods for subject characterization, and how to continue modifications of the cohort as the HIV epidemic continues to evolve.