Case Center for Synchrotron Bioscience

描述（由申请人提供）：同步加速器生物科学中心（CSB）在国家同步加速器光源（NSLS）和凯斯西储大学（CWRU）拥有最先进的设施和实验室，建议通过更新其P30中心拨款，继续其在布鲁克海文国家实验室（BNL）开发和操作一套同步加速器光束线和相关技术的计划。自1994年以来，在美国国立卫生研究院（NCRR/NIBIB）的持续资助、美国国家科学基金会的大力支持以及与许多学术机构和BNL的合作下，该中心通过设计、建造和运行多个光束线，支持了一个大型的国际结构生物学用户社区。该中心通过不断升级、维护和运行光束线，为NSLS的500多名生命科学用户提供服务，这些光束线提供光子、先进的终端仪器、用户支持和最先进的同步加速器生物物理技术培训。在这份更新提案中，CSB将继续研究同步加速器x射线足迹、x射线光谱学和大分子晶体学。行政核心将支持这些核心，传播和培训核心将补充其活动。在研究基地，对于三个核心来说，

DESCRIPTION (provided by applicant): The Center for Synchrotron Biosciences (CSB), with state-of-the-art facilities and laboratories at the National Synchrotron Light Source (NSLS) and at Case Western Reserve University (CWRU), proposes to continue its programs of developing and operating a suite of synchrotron beamlines and associated technologies at Brookhaven National Laboratories (BNL) through a renewal of its P30 Center grant. Since 1994, with continuous funding from the NIH (NCRR/NIBIB), significant support from NSF and in partnership with many academic institutions and BNL, the Center has supported a large, international structural biology user community through the design, construction, and operation of multiple beamlines. The Center serves over 500 life-science users at the NSLS through the continuous upgrade, maintenance, and operation of beamlines that provide photons, advanced end-station instrumentation, and user support and training for a range of synchrotron biophysics technologies at the state-of-the-art. In this renewal proposal, the CSB will continue technology sores for: synchrotron X-ray footprinting, X-ray spectroscopy, and macromolecular crystallography. An Administrative Core will support these cores and Dissemination and Training Cores will supplement their activities. In the Research Base, for the three cores overall, we identify 176 PIs with 245 specific sources of funding (projects) including 230 peer-reviewed project grants (~200 from NIH). We propose to support 145 projects in macromolecular crystallography (100 PIs), 52 projects in X-ray footprinting (43 PIs), and 48 projects in X-ray spectroscopy (33 PIs) for the renewal. The opportunity to considerably enhance the facilities available to this Research Base is based on a once in a generation opportunity provided by the opening of a new synchrotron ring, the NSLS-II. The CSB team, in collaboration with BNL has secured funding for new beamlines at this facility. During the first part of the renewal period, the CSB will complete beamline design, purchase and fabricate equipment, and then by the mid-point of the grant period complete installation, then commission several state-of-the art beamlines. We will make the transition to vibrant user programs by the end of the grant period with robust scientific facilities, active dissemination and training program and novel scientific results. The outcome of the five-year period will be a Center that continues to be a magnet for world-class synchrotron biosciences research well beyond existing capabilities and productivity that can continue for many years into the future.