Research in the Pathogenesis of Hematologic Disorders

描述（由申请人提供）：纽约大学医学院在培养学术血液学家方面有着悠久的历史。在很大程度上，这一记录是由1962年以来美国国立卫生研究院培训基金（T32）的持续支持促成的，该基金支持6名医学博士、医学博士、博士和博士实习生。培训计划的长期目标是为血液学学员将来在学术医学领域的职业生涯做好准备。在统一的培训计划中，医学博士、医学博士/博士和博士实习生之间的相互作用有助于增加致力于研究事业的医生和科学家的数量。培训计划让学员接触到严格指导的血液学实验室研究，详细的课程，系列研讨会，期刊俱乐部，临床管理会议，以及参与（医学博士学员）或观察（博士学员）与临床血液学相关的实验室调查实践的机会。学员从ACGME认可的成人和儿童血液学/医学肿瘤学奖学金项目中选择，并从参与教师实验室的合格博士后博士研究员中选择。该项目由一名主任和三名非常合格的副主任领导，专门致力于积极招募代表性不足的少数民族。我们的15位导师都有指导和记录生产力的经验，他们的实验室是高度互动的，并使用各种模型系统来研究1)良性血液学，包括PNH，血小板生物学和范可尼贫血；2)白血病的遗传学；3) JAK/STAT和Ras信号在造血干细胞、淋巴细胞、白血病和淋巴瘤中的作用机制；4)淋巴生成和淋巴细胞活化（包括GVHD）；5)髓细胞和淋巴细胞运输的机制；6)泛素化在造血干细胞生物学、淋巴生成和白血病/淋巴瘤中的应用；7)正常和异常造血的表观遗传学和分子基础。我们项目过去的毕业生都取得了最高的学术水平，并为血液学领域做出了持久的贡献，而且我们最近的毕业生中有很大一部分留在学术界，在研究人员、学术教师和试验人员的职业生涯中使用作为实习生获得的研究技能。在过去的十年中，我们的大多数毕业生都在学术机构获得了职位，在最高级别的期刊上发表了他们的研究成果，并获得了多项NIH和基金会奖项。

DESCRIPTION (provided by applicant): The New York University School of Medicine has a long established record of training academic hematologists. In large part, this record has been fostered by the continuous support, since 1962, of a NIH Training Grant (T32) which supports 6 M.D., M.D., PhD, and PhD Trainees. The long term goal of the Training Program is to prepare Hematology Trainees for future careers in academic medicine. The interaction of both M.D., M.D./PhD, and PhD Trainees in a unified Training Program serves to increase the number of physicians and scientists committed to a career in research. The Training Program exposes Trainees to rigorous mentored lab based hematology research, a detailed curriculum, seminar series, a journal club, a clinical management conference, and the opportunity to participate (for M.D Trainees) or observe (for PhD Trainees) the practice of clinical hematology relevant to the Trainee's laboratory investigation. Trainees are selected from the ACGME accredited adult and pediatric hematology/medical oncology fellowship programs and from eligible post- doctoral PhD fellows in participating faculty member's laboratories. The program, led by a Director with three well qualified Associate Directors, is specifically dedicated to actively recruiting underrepresented minorities. Our 15 Mentors have experience in mentoring and documented productivity, and their laboratories are highly interactive and use a variety of model systems to study 1) benign hematology including PNH, platelet biology and Fanconi anemia; 2) the genetics of leukemia; 3) JAK/STAT and Ras signaling mechanisms in hematopoietic stem cells, lymphopoieis, leukemia and lymphoma; 4) lymphopoiesis and lymphocyte activation (including GVHD); 5) mechanisms of myeloid and lymphoid trafficking; 6) ubiquitination in hematopoietic stem cell biology, lymphopoiesis, and leukemia/lymphoma; and 7) the epigenetic and molecular basis of normal and abnormal hematopoiesis. Past graduates of our program have achieved the highest ranks of academia and have made lasting contributions to the field of hematology, and a high proportion of our recent graduates remain in academia, using the research skills gained as Trainees in careers as researchers, academic teachers and trialists. Over the last 10 years the majority of our graduates have obtained positions in academic institutions, have published their findings in the highest tier of journals, and have received multiple NIH and foundation awards.