Muller cell reactivity during diabetic retinopathy

糖尿病是导致劳动人口失明的主要原因。在一些糖尿病患者中，视网膜内的血管增生、出血或引起视网膜脱离。视网膜内导致血管增生的潜在变化尚不清楚。导致视网膜血管变化的因素之一是视网膜内被称为穆勒细胞的细胞中生长因子的增加。Muller细胞对视网膜的正常功能至关重要，并且在糖尿病晚期异常。它们也可能在糖尿病早期功能失调，并可能在引起糖尿病早期变化方面发挥重要作用。因此，了解Muller细胞如何变化以及它们发生变化的时间对于更好地了解与糖尿病相关的缺陷至关重要。此外，了解糖尿病中发生的基本潜在细胞变化将有助于未来开发更特异性的治疗药物。

Diabetes is the leading cause of blindness in the working population. In some patients with diabetes, blood vessels within the retina proliferate, haemorrhage or cause retinal detachment. The underlying changes within the retina that lead to the proliferation of blood vessels are not well understood. One of the factors that leads to changes in retinal blood vessels is an increase in growth factors from cells within the retina called Muller cells. Muller cells are vital for the normal function of the retina and are known to be abnormal late in diabetes. They may also be dysfunctional early in diabetes and could play a significant role in causing the early changes seen in diabetes. Therefore a good understanding of how Muller cells change and the time at which they change is vitally important to gain a better understanding of the defects that are associated with diabetes. Furthermore, an understanding of the basic underlying cellular changes that occur in dibaetes will aid the development of more specific therapeutic agents in the future.