Dissecting the establishment and regulation of human pluripotency

摘要： 我们已经提出了一个全面的方案项目，将继续解决基本问题 关于建立和维持多面性国家。我们的四个项目组件带来了 不同的专业知识，从表观遗传学、非编码DNA、非编码RNA和计算生物学到 了解重新编程和多能细胞背后的分子电路。然而，总有一些 该计划有许多可能的扩展，以进一步增强其对再生生物学和人类的影响 总体上是健康的。 为了允许继续扩展到这些未知或新出现的领域，我们提出了一种行政管理 核心，目标是利用完善的试点赠款机制，吸引新的人才到外地工作，并 还通过提供种子基金对新趋势做出快速反应。我们进一步将这些试点计划整合到 并通过频繁的互动在我们的科学中传播。最后，我们的目标是将科学家聚集在我们的 与实验室内部务虚会、当地会议、研讨会和我们的国际研讨会一起努力。 考虑到与试点接受者的互动(包括已有的几个联合出版物)，我们认为他们是 作为一个整体，该计划大大丰富了内容。好处是互惠的，与该计划的互动 PIS以及财政支持显然正在帮助试点PIS的努力，这些PIS通常是新的 菲尔德。我们的实验室间会议、务虚会和主要研讨会都是整合所有 将参与者和努力投入到一个具有高度影响力的整体研究计划中。 行政核心在正在进行的项目中的使用在所有各级都非常成功，我们 基本上建议在目前的提案中以相同的结构继续执行该方案。 总而言之，我们很高兴有机会拥有管理组件，并将继续 利用它来最大限度地造福于干细胞和更大的科学界。

Abstract: We have proposed a comprehensive program project that will continue to address fundamental questions regarding the establishment and maintenance of the pluripotent state. Our four project components bring diverse expertise ranging from epigenetics, noncoding DNA, noncoding RNA and computational biology to understand the molecular circuits underlying reprogramming and pluripotent cells. There are however always many possible extensions of this program to further enhance its impact on regenerative biology and human health in general. To allow a continual expansion into these unknown or newly emerging areas we propose an administrative core with the objective to use a well-established pilot grant mechanism to attract new talent to the field and also respond rapidly to new trends by providing seed funds. We further integrate these pilot programs within and across our science through frequent interactions. Finally we aim to bring together scientists around our efforts with intra-lab retreats, local meetings, workshops and our international symposium. Given the interactions with the pilot recipients (including already several joint publications) we feel they are a significant enrichment of the program as a whole. The benefit is mutual and the interactions with the program PIs as well as the financial support is clearly helping the efforts of the pilot PIs, which are generally new to this field. Our inter labmeetings, retreats and also the main Symposium are effective ways the integrate all of the involved players and efforts into a high impact overall research program. The use of the administrative core in the ongoing project has been highly successful on all levels and we essentially propose to continue the program in the same structure in the current proposal. In summary, we are thrilled about the opportunity to have the administrative component and will continue to use it to the maximal benefit of the stem cell and larger scientific community.