Patient Registry-Virtual Biorepository

摘要-患者登记-虚拟生物库核心将支持收集人类食管癌 标本用于中心的转化研究项目以及集中的BETRNet 该计划的虚拟存储库将位于BETRNet协调中心。该核心将提供 能够及时与BETRNet协调中心共享样本数据， 标本管理。该核心将提供临床数据、库存血清、血浆、体细胞DNA、冷冻 粘膜标本和福尔马林固定石蜡包埋（FFPE）粘膜标本， 有和没有BE的患者队列。该核心还将提供来自以下人群的横断面队列数据： 从BE到EAC的连续体中的患者，以促进有希望的细胞表面靶标的鉴定。 该核心还将维护、更新和提供临床数据和FFPE粘膜标本， BE患者的纵向队列，包括进展为瘤形成的患者。

Abstract – The Patient Registry-Virtual Biorepository Core will support collection of human esophageal specimens for use in the Center's translational research projects as well as for the centralized BETRNet program's virtual repository to be located at the BETRNet Coordinating Center. This Core will provide capabilities for timely sharing of specimen data with the BETRNet Coordinating Center for trans-BETRNet specimen management. This Core will provide clinical data, banked serum, plasma, somatic DNA, frozen mucosal specimens, and formalin-fixed paraffin-embedded (FFPE) mucosal specimens from a cross-sectional cohort of patients with and without BE. This Core will also provide data from a cross-sectional cohort of patients in a continuum from BE to EAC in order to facilitate identification of promising cell surface targets. This Core will also maintain, update, and provide clinical data and FFPE mucosal specimens from a longitudinal cohort of patients with BE, including those who progress to neoplasia.