Translational Basic and Clinical Research Training in Rheumatology

本申请表适用于风湿病学的基础和临床研究翻译培训 纽约大学风湿科主任Jill Buyon博士的领导，他带来了翻译 在系统性红斑狼疮方面的专业知识和长期的指导-基于多年的快速增长和专注 目标明确的思考：通过向领导角色和领导角色的扩展发展来支持学员 在科学和医学方面做出了有意义的贡献。因为标准的两年奖学金根本不够用 为了使研究员为学术生涯做好准备，该计划满足了延长传统ACGME培训的需要。 我们寻求对3名博士研究生和1名博士后医学博士/博士研究生的支持，以建立早期渠道 风湿病。在NIAMS T32不间断资助30年后的短暂中断期间，该司 领导层换届；ACGME奖学金从每年3个职位重新扩大到4个职位；促进晋升 新的终身教职任命的初级教员；招聘教员来填补风湿病领域未得到满足的需求- 专注于基础科学；建立了包括Micra(纽约大学微生物组)在内的翻译研究中心 风湿学和自身免疫中心)、科尔顿自身免疫中心和银屑病关节炎 中心；和机构样本(样本和匹配的表型连锁评估)，IRB批准 利用统一同意为临床和BASE提供共享的部门范围资源的生物信息库 研究人员。这一建议的核心是跨学科培训，同时进行两项在方法上截然不同的研究 轨道：重振基础科学职业道路，临床研究鼓励与以下相关的研究 差距和社区参与度与我们所服务的人群一致。在许多情况下，丰富的 培训将包括高级学位。每一首曲目都有“翻译的”前缀--无论是基本的还是临床的--以 强调所有医疗保健调查人员的共同目标。一条早期科学家之路将提供给 博士/博士候选人(仅限翻译-基础课程)，招聘工作通过与 纽约大学免疫学/炎症和细胞/分子生物学医学/博士和研究生项目主任。 这两个路径都以反映教师专业知识和公认领导力的核心疾病群为基础：1) 狼疮和系统性自身免疫性疾病；2)炎症性和自身免疫性关节炎；3)退行性 和代谢性骨病。每一首曲目都包含了通用的和高度定制的教学内容；个性化 与主要、助理和方法导师组成的项目团队进行研究培训的经验将带来 临床背景到替补席，反之亦然；一个咨询职业发展委员会；并计划 支持T32后晋升到教员职位。计划的成功将按季度进行评估 执行委员会会议、外部咨询委员会半年度会议和年度会议 撤退。机构承诺很强，支持基础设施和为医生提供内部资金- 科学家。纽约大学-HHC CTSI为拟议的培训计划提供了广泛的资源。

This application for Translational Basic and Clinical Research Training in Rheumatology, under the leadership of Dr. Jill Buyon – Director of the Division of Rheumatology at NYU, who brings translational expertise in SLE and long-standing mentorship – is based on several years of rapid growth and attentive reflection with clear purpose: to support trainees through extended development toward leadership roles and meaningful contributions in science and medicine. Since the standard 2-year fellowship is simply not adequate to prepare fellows for academic careers, this program addresses the need to extend traditional ACGME training. We seek support for 3 physician postgraduates and 1 pre-doctoral MD/PhD trainee to establish an early pipeline to Rheumatology. During a brief hiatus after >30 years of uninterrupted NIAMS T32 funding, the Division has transitioned leadership; re-expanded the ACGME fellowship from 3 to 4 positions annually; fostered advancement of junior faculty with new tenure-track appointments; recruited faculty to fill unmet needs in rheumatology- focused basic science; established centers of translational research that include MiCRA (NYU Microbiome Center for Rheumatology and Autoimmunity), the Colton Center for Autoimmunity, and the Psoriatic Arthritis Center; and instituted SAMPLE (Specimen And Matched Phenotype Linked Evaluation), an IRB-approved biorepository utilizing a uniform consent to provide a shared division-wide resource for clinical and bench researchers. At the core of this proposal is interdisciplinary training along two methodologically distinct research tracks: reinvigoration of basic science career pathways, and clinical research encouraging inquiry relating to disparities and community engagement consistent with the populations we serve. In many cases the enriched training will include an advanced degree. Each track bears the prefix “translational” – be it basic or clinical – to emphasize the common purpose of all healthcare investigators. An Early Scientist Pathway will be offered to MD/PhD candidates (translational-basic track only), with recruitment accomplished by partnering with the directors of the NYU MD/PhD and graduate programs in Immunology/Inflammation and Cell/Molecular Biology. Both tracks are grounded in core disease clusters reflecting faculty expertise and recognized leadership: 1) lupus and diseases of systemic autoimmunity; 2) inflammatory and autoimmune arthritis; and 3) degenerative and metabolic bone disease. Each track incorporates common and highly customized didactics; individualized research training experiences with a project team of Primary, Associate, and Methodological Mentors to bring clinical context to the bench and vice versa; an Advisory Career Development Committee; and planning to support post-T32 advancement to faculty positions. Programmatic success will be evaluated though quarterly meetings of the Executive Committee, semiannual meetings of the External Advisory Committee, and an Annual Retreat. Institutional commitment is strong with support for infrastructure and internal funding for physician- scientists. The NYU-HHC CTSI provides extensive resources available for the proposed training program.