Hopkins Digestive Diseases Basic & Translational Research Core Center

 描述(由申请人提供)：NIDDK霍普金斯消化疾病基础和翻译研究核心中心(DDBTRCC)于9/1/11获得资助，目的是促进霍普金斯大学的胃肠道科学，并以翻译的方式应用研究发现，为改善胃肠道疾病患者的健康奠定基础。该中心目前的具体目标是利用我们的进步，扩大JHU在基础和翻译上皮生物学方面的GI研究，这是中心研究人员的几个优势领域。这些优势体现在我们的焦点小组中，这些小组包括(I)上皮运输：功能和调节(重点是转运蛋白运输、蛋白质-蛋白质相互作用和金属运输)，(Ii)炎症、损伤和纤维化，(Iii)神经胃肠病，以及(Iv)GI分化、增殖、癌症前病变(重点是信号通路、表观遗传学和生物标记物)。该中心的研究基地由59名研究人员(45名成员和14名准成员)组成，其中包括来自基础科学(25名)和临床科室(34名)的教员。该研究基地由4个科学核心支持：蛋白质组学核心(JHU质谱学核心的一部分)、成像核心、综合生理学核心、翻译研究促进核心(TREC)和一个管理核心。我们在核心提供的服务中增加了主要的新领域，包括蛋白质组分析，重点是翻译后修饰，开发人类肠样组织作为胃肠道生理学和病理生理学的有前景的模型，以及使这些新模型可供我们的研究人员使用的实践培训。通过增加设备(包括双光子、旋转圆盘共焦和超分辨率显微镜以及高端荧光平板阅读器)和在我们的成像核心建立奥林巴斯显微镜演示中心(奥林巴斯中心是国内第二个提供最新奥林巴斯显微镜供我们的研究人员使用的中心)，成像核心的能力得到了显著提高。我们的TREC仍然是JHU/CTSA为整个机构发展翻译研究的核心。行政核心组织试点/可行性和丰富方案(每周进行中工作、年度全天研讨会、霍夫曼讲座和胃肠科学日加海报会议)。P/F计划已经资助了15个项目，其中13个是给新的研究人员，2个是给更资深的教员，他们的工作对GI来说是新的，将开发对许多中心研究人员重要的创新技术。到目前为止，已完成的11个P/F项目产生了8.7倍的投资回报。我们的中心已经获得了新的空间，在一个地点增加到大约3000平方英尺(面积翻了一番)。我们的整体消化疾病(DD)资金增加了68%，达到2523万美元，我们的NIH DD资金增加了58%，达到720万美元，其中39%是NIDDK DD资金。

 DESCRIPTION (provided by applicant): The NIDDK Hopkins Digestive Diseases Basic and Translational Research Core Center (DDBTRCC) was funded on 9/1/11 with the goal to facilitate GI science at Hopkins and apply research discoveries in a translational manner to form the background for improving the health of GI patients. The current Specific Aims of the Center are to capitalize on our advances and expand GI research at JHU in basic and translational epithelial biology in several areas of strength of Center investigators. These strengths are represented in our Focus Groups that include (i) Epithelial Transport: Function and Regulation (with the emphasis on transporters trafficking, protein-protein interactions and metal transport), (ii) Inflammation, Injury and Fibrosis, (iii) Neurogastroenterology, and (iv) GI Differentiation, Proliferation, Pre-cancer (with emphasis on signaling pathways, epigenetics, and biomarkers). The Center research base consists of 59 investigators (45 Members and 14 Associate Members), with a mix of faculty from basic science (25) and clinical departments (34). The Research Base is supported by 4 Scientific Cores: Proteomics Core (part of the JHU Mass Spectrometry Core), Imaging Core, Integrated Physiology Core, Translational Research Enhancement Core (TREC) and an Administrative Core. We have added major new areas to the services provided by the Cores that include proteomic analysis with an emphasize on post-translational modification, development of human enteroids as promising models of GI physiology and pathophysiology, and the hands-on training which makes these new models available to our investigators. The capabilities of the Imaging Core have been significantly increased by additional equipment (including two photon, spinning disk confocal and super resolution microscopes as well as a high-end fluorescence plate reader) and establishment of an Olympus Microscopy Demonstration Center in our Imaging Core (The Olympus Center is only the second such Center in the country to provide the newest Olympus microscopes for use by our investigators). Our TREC remains central to the JHU/CTSA development of translational research for the entire institution. The Administrative Core organizes the Pilot/Feasibility and Enrichment Programs (weekly Work-in-Progress, annual all day symposium, Hofmann Lecture and day of GI science plus poster session). The P/F program has funded 15 projects, 13 of those to new investigators and 2 to more senior faculty whose work is new to GI and will develop innovative technologies important for many Center investigators. To date, the 11 completed P/F projects have produced an 8.7-fold return on investment. Our Center has been given new space increasing it to ~3000 sq ft (doubling in size) in a single location. Our overall digestive disease (DD) funding has increased by 68% to $25.23 million, our NIH DD funding - by 58% to $7.2 million, of which 39% is NIDDK DD funding.