Center for Molecular Imaging Technology and Translation (CMITT)

分子影像技术与翻译中心项目概要/摘要 分子成像技术和翻译中心（CMITT）将成为国家资源， 在马萨诸塞州总医院新成立的戈登医学成像中心（GCMI）内。 在跨学科环境中工作（例如，图像重建与处理; 药代动力学）的戈登中心，CMITT的目的是开发，验证和传播尖端 成像技术，利用改变游戏规则的能力，同时获得 PET和MR. CMITT由三个技术研究和开发项目（TR& D）组成：TR & D 1旨在 打破PET的分辨率障碍。通过开发衰减和运动场的使能技术， 估计以及PSH建模，我们可以实现PET的固有分辨率，约4 mm，在呼吸 通过使用具有稀疏采样的新型加速MR采集，TR&D2将制定统一的统计 PET和MR的联合重建模型，包含TR &D1中开发的校正。TR&D3将 开发同步PET/MR（TR & D3）中生理过程的药代动力学建模， PET/MR图像可用于探索分子生理学。 目前没有以PET为重点的生物医学技术资源中心得到NIBIB的支持。因此，CMITT 旨在满足PET/MR成像技术发展的明确国家需求，这是一个不可知的方面， 在商业平台上，并且在许多情况下同样适用于单独的PET或MR。资源提供了一个独特的 环境与高度成就的科学家，工程师和临床医生的跨学科团队，具有不同的 在多种模式和学科的专业知识，支持通过成像服务使用中心的设施 科学家遍布全国以及欧洲，亚洲和澳大利亚。CMITT将提供广泛的培训 为学生，博士后研究员和教师提供机会，并寻求推进分子成像领域的发展。 通过积极传播新知识和新技术，

Project Summary / Abstract for the Center for Molecular Imaging Technology and Translation The Center for Molecular Imaging Technology and Translation (CMITT) will be a national resource located within the newly created Gordon Center for Medical Imaging (GCMI) at the Massachusetts General Hospital. Working within the interdisciplinary environment (e.g., imaging sciences; image reconstruction and processing; pharmacokinetics) of the Gordon Center, the aim of CMITT is to develop, validate and disseminate cutting-edge imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of PET and MR. CMITT consists of three Technology Research and Development projects (TR&Ds): TR&D1 aims at breaking down the resolution barrier in PET. By developing enabling technologies for attenuation and motion field estimation as well as PSH modeling we can achieve the intrinsic resolution of PET, about 4mm, in the breathing patient by using novel accelerated MR acquisitions with sparse sampling. TR&D2 will develop the unified statistical model of joint reconstruction of PET and MR that incorporates the corrections developed in TR&D1. TR&D3 will develop the pharmacokinetic modeling of physiological processes in simultaneous PET/MR (TR&D3) in quantitative PET/MR images that enable exploration of molecular physiology. There is currently no PET-focused Biomedical Technology Resource Center supported by NIBIB. Thus CMITT seeks to fill a clear national need for PET/MR imaging technology development, one that is agnostic with respect to commercial platform and, in many instances, applies equally to PET or MR alone. The Resource provides a unique environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging scientists throughout the country as well as Europe, Asia and Australia. CMITT will provide extensive training opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of normal function and disease through active dissemination of new knowledge and technology.