Computation, Bioinformatics, and Statistics (CBIOS) Training Program

描述（由申请人提供）：基因组数据正在改变医学和基础科学科学家进行研究的方式。基因组科学的进步需要新一代具有强大的计算和统计技能以及与实验人员有效互动的能力的科学家。宾夕法尼亚州立大学计算、生物信息学和统计学（CBIOS）培训计划将培养一批具有创新思维的研究人员，并与快速发展的高通量基因组技术保持同步。该计划的教师是跨学科和高度协作的，具有计算，生物信息学，统计学，功能，医学和进化基因组学方面的专业知识。学习这些跨学科技能将使学员在比较、系统、统计和医学基因组学等新兴和快速发展领域的未来职业中具有竞争力。CBIOS计划的教育目标是在学员中产生以下几点：1。彻底理解科学过程中的假设检验。2. 从理论到数据再到数据的能力。3. 熟练使用计算和统计工具处理高通量数据。4. 整合和创新高通量数据的计算和统计分析能力。5. 卓越的跨学科科学交流，包括计算和生物信息学研究的伦理影响。

DESCRIPTION (provided by applicant): Genomic data are transforming how scientists in medicine and basic science conduct research. The advancement of genome science requires a new generation of scientists with strong computational and statistical skills and the ability to effectively interact with experimentalists. The proposed Penn State Computation, Bioinformatics, and Statistics (CBIOS) Training Program will prepare a cadre of investigators to think innovatively and keep pace with the quickly evolving landscape of high throughput genomic technologies. The program faculty are interdisciplinary and highly collaborative, with expertise in computation, bioinformatics, statistics, functional, medical, and evolutionary genomics. Learning these discipline-crossing skills will make trainees competitive for future careers in emerging and rapidly advancing fields of comparative, systems, statistical and medical genomics. The educational objectives of the CBIOS program are to engender in the trainees the following: 1. A thorough understanding of hypothesis testing in the scientific process. 2. The ability to work from theory to data and back. 3. Fluency in the use of computational and statistical tools for high throughput data. 4. The ability to integrate and innovate computational and statistical analysis of high throughput data. 5. Excellence in cross-disciplinary scientific communication including ethical implications of computational and bioinformatics research. 6. The ability to lead cross-disciplinary research teams The CBIOS training program will accomplish these objectives through a set of existing core and elective courses along with a new practicum course, all of which are integrated with a journal club and seminar series. The program will enhance professional development through invited seminar speakers and retreats, and will specifically develop trainees' communication skills to enable dissemination of genomics research to a broad audience. Predoctoral trainees will be selected early in their graduate program for two years of intensive training. A total of 15 trainees (10 NIH and 5 PSU supported) will be trained during a five-year granting period. The faculty supporting this training program have a combined annual research funding base of $65 million direct costs, and thus offer a robust mentoring foundation for student research experience and opportunities.