CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGY RESEARCH

 描述(由申请人提供)：这份T32申请旨在使儿科风湿病研究员具备必要的调查技能，以便在儿科风湿病学术科学生涯中取得成功。该计划的基础是儿科风湿病(PR)的一个大部门，有几个中心拨款(P30，P01)和NIH资助的研究人员。儿科风湿科，包括其相关的诊所，是辛辛那提儿童医院医疗中心(CCHMC)和儿童医院研究基金会(TCHRF)的一部分，也是辛辛那提大学医学院(UCCOM)的一部分，设有临床和生物医学科学系。儿科风湿病科研究计划的力量来自临床、翻译和基础研究人员的独特整合团队，他们参与了与免疫生物学、人类遗传学、血液学/肿瘤学、骨髓移植、肾病学、药理学、放射学、心理学和生物信息学部门成员的积极持续合作。主要的教师顾问是从15个专业部门中挑选出来的，基于与风湿学教师的持续合作、高研究生产率和年轻科学家的良好培训记录。虽然公关奖学金计划的主要重点是医学博士和医学博士/博士实习生，但对儿科风湿病的翻译研究有浓厚兴趣的博士候选人也将被寻找。大多数学员将把他们的研究和培训活动集中在CCHMC研究中心和风湿病学部独有的两个特别强调的优势领域之一：(1)应用生物信息学和“组学”技术，包括基因组学、表观遗传学、蛋白质组学和代谢组学，以推进与儿科风湿病相关的转化性研究；(2)临床流行病学，临床结果评估工具的开发和临床试验设计。该计划得到了核心设施以及学术课程的良好支持，其中包括一门医德必修课。其他课程包括计算系统生物学、免疫生物学、分子遗传学、流行病学和生物统计学。以CCHMC为中心的跨部门免疫生物学研究生课程(硕士和博士)是对现有流行病学和生物统计学以及加州大学圣迭戈分校教育课程的补充。据信，这一儿科风湿病研究培训计划提供了独特的资源，并将继续扩大对生物医学科学有职业兴趣的个人池，因为它与儿科风湿病有关，随着分子医学在临床上的应用越来越多，这个池太小了，无法满足未来几十年的要求。

 DESCRIPTION (provided by applicant): This T32 application seeks to equip pediatric rheumatology fellows with the investigative skills necessary to succeed in meaningful scientific careers in academic pediatric rheumatology. The program is based in a large Division of Pediatric Rheumatology (PR) with several center grants (P30, P01) and NIH-funded investigators. The Pediatric Rheumatology Division, including its related clinic, is part of Cincinnati Children's Hospital Medical Center (CCHMC) and The Children's Hospital Research Foundation (TCHRF), as well as part of the University of Cincinnati College of Medicine (UCCOM) with its clinical and biomedical science departments. The Pediatric Rheumatology divisional research program draws strength from uniquely integrated teams of clinical, translational and basic researchers involved in active ongoing collaborations with members of Divisions of Immunobiology, Human Genetics, Hematology/Oncology, Bone Marrow Transplantation, Nephrology, Pharmacology, Radiology, Psychology and Bioinformatics. The primary faculty advisors were selected from 15 specialties divisions based on the ongoing collaboration with Rheumatology faculty, high research productivity and strong record of training of young scientists. Although the main emphasis will be placed on MD and MD/PhD trainees in the PR Fellowship Program, PhD candidates with strong interest in translational research in pediatric rheumatologic diseases will be sought as well. The majority of trainees will focus their research and training activities in one of the two special emphasis areas of strength, unique to the CCHMC research center and the Division of Rheumatology: (1) application of bioinformatics and "omics" technologies including genomics, epigenetics, proteomics, and metabolomics to advance translational research related to pediatric rheumatology, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. The program is well supported by core facilities as well as by academic courses, including a mandatory course in medical ethics. Other available courses include computational system biology, immunobiology, molecular genetics, and epidemiology and biostatistics. The interdepartmental Immunobiology Graduate Program (MS and PhD) that is centered at CCHMC complements existing programs in Epidemiology and Biostatistics, and Education in the UCCOM. It is believed that this Training Program for Pediatric Rheumatic Disease Research provides unique resources and will continue to enlarge the pool of individuals with a career interest in biomedical science as it relates to pediatric rheumatology, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.