Biostatistics and Bioinformatics (BBSR)

项目概要/摘要：生物统计学和生物信息学 生物统计学和生物信息学共享资源（BBSR）提供全面的统计和 为所有诺里斯棉花癌症中心（NCCC）提供生物信息学咨询、合作和技术服务 程序.所有BBSR统计学家和生物信息学家都配备了最先进的工作站， 通用和专业统计软件包，如SAS、R、RStudio、PASS、NQuery、SPSS、MPlus和 Winbug高性能计算依赖于对2000+处理器并行计算机集群的访问 （Discovery）.来自生物医学数据科学系、达特茅斯研究所和 儿科在临床试验和研究设计中担任科学合作者，建议并参与 统计研究管理、执行统计监督和进行数据分析。State-of-the-art BBSR教师的能力是显而易见的，他们获得了两个PCRI方法奖，两个NIH R 01， 在当前的融资期内，两个单独的K 01。自上次审查以来，四名新教师加入了 共享资源（即，Frost [CBT]，Emond [CPS]，Gorlov [CPS]和Moen [CPS]），加强 支持行为研究和网络分析，以前将生物统计学和生物信息学分开 资源已合并，以更好地协调教师的专业知识，并利用行政 效率。超过300篇同行评审的癌症相关出版物，其中包括BBSR教师作为共同作者 出现在本报告所述期间。BBSR影响的广度在以下例子中显而易见： 发展与癌症人口科学研究人员在专门统计方法方面的合作 为了分析生活质量的终末下降，用癌症患者进行基因集富集分析， 生物学和治疗学计划，以确定提供潜在治疗机会的途径，以及 先进的图像处理和机器学习，以协助癌症研究人员的转化工程 在癌症检测中。生物医学科学新部门的生物统计学部门作为 BBSR的组织之家，但10名教师中有9人住在NCCC鲁宾大楼。托尔医生 Tosteson（CPS）担任共享资源总监已有20多年。教师每月开会， 协调活动，第二个教员提供协议的独立审查，并在内部- 与BBSR共同研究者资助的项目。在本报告所述期间， 服务时的NCCC成员（CPS [62]，CBT [33]，ICI [16]，TEC [15]）。56名NCC成员 出版了300份出版物，就62份赠款申请进行了合作。受资助的NCCC成员占29%（73） 总用户，我们只要求CCSG支持总BBSR预算的13%。的新倡议 增加对NCCC成员的服务，包括正式指定BBSR教师参与指导 委员会。此外，正在建立无需预约的诊所，以提供主要需要快速咨询的短期咨询 对于统计复杂程度很高的研究人员来说。

Project Summary/Abstract: Biostatistics and Bioinformatics The Biostatistics and Bioinformatics Shared Resource (BBSR) offers comprehensive statistical and bioinformatics consultation, collaboration, and technical services to all Norris Cotton Cancer Center (NCCC) Programs. All BBSR statisticians and bioinformaticians are equipped with state-of-the-art workstations with general and specialty statistical packages, such as SAS, R, RStudio, PASS, NQuery, SPSS, MPlus, and Winbugs. High-performance computing relies on access to a 2000+ processor parallel computer cluster (Discovery). Ten (10) faculty from the Departments of Biomedical Data Sciences, The Dartmouth Institute, and Pediatrics serve as scientific collaborators in clinical trial and research design, advise on and participate in statistical study management, perform statistical oversight, and conduct data analyses. State-of-the-art capabilities are evident in BBSR faculty having obtained two PCORI Methodology Awards, two NIH R01s, and two individual K01s during the current funding period. Since the last review, four new faculty have joined the Shared Resource (i.e., Drs. Frost [CBT], Emond [CPS], Gorlov [CPS] and Moen [CPS]), strengthening support for behavioral research and network analysis, and formerly separate Biostatistics and Bioinformatics resources have been merged to better coordinate faculty expertise and take advantage of administrative efficiencies. More than 300 peer-reviewed cancer-related publications involving BBSR faculty as co-authors appeared in the current reporting period. The breadth of BBSR impact is evident in examples of the development of collaboration with Cancer Population Sciences investigators on specialized statistical methods for analyzing terminal declines in quality of life, gene set enrichment analyses performed with the Cancer Biology and Therapeutics Program to identify pathways presenting potential therapeutic opportunity, and advanced image processing and machine learning to assist Translational Engineering in Cancer investigators in cancer detection. The Division of Biostatistics in the new Department of Biomedical Science serves as the BBSR organizational home, but nine of the 10 faculty are housed on site in the NCCC Rubin Building. Dr. Tor Tosteson (CPS) has served as Shared Resource Director for more than 20 years. Faculty meet monthly to coordinate activities, and a second faculty member provides an independent review of protocols and internally- funded projects with a BBSR co-investigator. During the current reporting period, 126 BBSR clients were NCCC Members at the time of service (CPS [62], CBT [33], ICI [16], TEC [15]). 56 NCCC Members, in addition to 300 publications, collaborated on 62 grant applications. Funded NCCC Members represented 29% (73) of Total Users, and we are requesting only 13% of the Total BBSR budget from CCSG support. New initiatives to augment services to NCCC Members include formal designation of BBSR faculty for participation on mentoring committees. Additionally, walk-in clinics are being established for short consult requiring primarily quick advice for researchers at many levels of statistical sophistication.