Interplay between lipophagy and mitophagy in skeletal muscle aging
Interplay between lipophagy and mitophagy in skeletal muscle aging
批准号:
10351860
负责人:
EDGAR A ARRIAGA
金额:
$2.76万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-04-15 至 2022-03-31
关键词:
Administrative SupplementAffectAgingAutophagocytosisCOVID-19 pandemicCellsCytometryDevelopmentFemaleLife StyleLogisticsMethodologyMononuclearMusMuscle functionMuscular AtrophyParentsPhysical PerformancePlayRoleSkeletal Musclecell typeexperimental studyinjury recoverymalemuscle agingmuscle formmuscular systemoperationparent grant
中文摘要
摘要:在本行政补充文件中,我们请求支持重复一个主要的
根据父母资助描述的实验:“脂肪吞噬和线粒体吞噬之间的相互作用,
骨骼肌老化”(5 R 01 AG 020866)。在这个实验中,老年人和年轻人(女性和男性)
C57 BL/6 J小鼠)分离单核细胞,然后通过质量分析
细胞计量术以在单细胞水平上探索每种细胞类型中自噬通量的变化。的
由于后勤工作的原因,最初的实验未能成功完成
新冠肺炎大流行
英文摘要
Summary: In this Administrative Supplement we are requesting support to repeat an major
experiment described under the parent grant: “Interplay between lipophagy and mitophagy in
skeletal muscle aging” (5R01AG020866). In this experiment, old and young (female and male
C57BL/6J mice) will be used to isolate mononuclear cells which then will be analyzed by mass
cytometry to explore, at the single cell level, changes in autophagy flux in each cell type. The
original experiment could not be completed successfully due to logistical operations brought up
by the Covid-19 pandemic.
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DOI:
10.1021/acs.analchem.6b00542
发表时间:
2016-06-21
期刊:
Analytical chemistry
影响因子:
7.4
作者:
[Daniele JR, Heydari K, Arriaga EA, Dillin A]
通讯作者:
Dillin A
Individual organelle pH determinations of magnetically enriched endocytic organelles via laser-induced fluorescence detection.
通过激光诱导荧光检测对磁性富集的内吞细胞器的单个细胞器 pH 值进行测定。
DOI:
10.1021/ac201196n
发表时间:
2011
期刊:
Analytical chemistry
影响因子:
7.4
作者:
[Satori,ChadP, Kostal,Vratislav, Arriaga,EdgarA]
通讯作者:
Arriaga,EdgarA
Fabrication of perforated sub-micron silica shells.
穿孔亚微米二氧化硅壳的制造。
DOI:
10.1016/j.scriptamat.2007.07.011
发表时间:
2007
期刊:
Scripta materialia
影响因子:
6
作者:
[Andreyev,DmitryS, Arriaga,EdgarA]
通讯作者:
Arriaga,EdgarA
DOI:
10.1021/acs.analchem.6b00837
发表时间:
2016-06-07
期刊:
Analytical chemistry
影响因子:
7.4
作者:
[Luo J, Muratore KA, Arriaga EA, Ros A]
通讯作者:
Ros A
DOI:
10.1021/ac901982u
发表时间:
2010-01-01
期刊:
ANALYTICAL CHEMISTRY
影响因子:
7.4
作者:
[Davis, Joe M., Arriaga, Edgar A.]
通讯作者:
Arriaga, Edgar A.
共 29 条
Subcellular Analysis of Caenohabdibtis elegans Aging Models
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批准号:8457310
-
项目类别:
-
资助金额:$6.2万
-
财政年份:2013
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Functional Proteomics of Aging
-
批准号:10430135
-
项目类别:
-
资助金额:$30.72万
-
财政年份:2008
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负责人:EDGAR A ARRIAGA
-
依托单位:
Functional Proteomics of Aging
-
批准号:9927539
-
项目类别:
-
资助金额:$44.88万
-
财政年份:2008
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负责人:EDGAR A ARRIAGA
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依托单位:
Functional Multi-omics of Aging
-
批准号:10628153
-
项目类别:
-
资助金额:$49.47万
-
财政年份:2008
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负责人:EDGAR A ARRIAGA
-
依托单位:
Aging of the subcellular muscle proteome
-
批准号:6862984
-
项目类别:
-
资助金额:$18.56万
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财政年份:2004
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负责人:EDGAR A ARRIAGA
-
依托单位:
Aging of the subcellular muscle proteome
-
批准号:6950861
-
项目类别:
-
资助金额:$14.85万
-
财政年份:2004
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Heteroplasmy at the single mitochondrion level
-
批准号:6724792
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项目类别:
-
资助金额:$10.81万
-
财政年份:2003
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Heteroplasmy at the single mitochondrion level
-
批准号:7025013
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项目类别:
-
资助金额:$10.81万
-
财政年份:2003
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Heteroplasmy at the single mitochondrion level
-
批准号:7214732
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项目类别:
-
资助金额:$10.81万
-
财政年份:2003
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Heteroplasmy at the single mitochondrion level
-
批准号:6556403
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项目类别:
-
资助金额:$10.81万
-
财政年份:2003
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Heteroplasmy at the single mitochondrion level
-
批准号:6877114
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项目类别:
-
资助金额:$10.81万
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财政年份:2003
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负责人:EDGAR A ARRIAGA
-
依托单位:
Defining heteroplasmy at the single mitochondrion level
-
批准号:6460975
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项目类别:
-
资助金额:$26.57万
-
财政年份:2002
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Defining heteroplasmy at the single mitochondrion level
-
批准号:6877116
-
项目类别:
-
资助金额:$28.27万
-
财政年份:2002
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Quantitating Mitophagy in Skeletal Muscle Models
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批准号:8442548
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项目类别:
-
资助金额:$2.32万
-
财政年份:2002
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负责人:EDGAR A ARRIAGA
-
依托单位:
Giant Mitochondria in Aging
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批准号:8216930
-
项目类别:
-
资助金额:$4.51万
-
财政年份:2002
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负责人:EDGAR A ARRIAGA
-
依托单位:
Interplay between lipophagy and mitophagy in skeletal muscle aging
-
批准号:9883690
-
项目类别:
-
资助金额:$30.19万
-
财政年份:2002
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负责人:EDGAR A ARRIAGA
-
依托单位:
Quantitating Mitophagy in Skeletal Muscle Models
-
批准号:8822184
-
项目类别:
-
资助金额:$40.19万
-
财政年份:2002
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Giant Mitochondria in Aging
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批准号:7882258
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项目类别:
-
资助金额:$1.21万
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财政年份:2002
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Defining heteroplasmy at the single mitochondrion level
-
批准号:6623080
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项目类别:
-
资助金额:$27.97万
-
财政年份:2002
-
负责人:EDGAR A ARRIAGA
-
依托单位:
Quantitating Mitophagy in Skeletal Muscle Models
-
批准号:8443386
-
项目类别:
-
资助金额:$34.92万
-
财政年份:2002
-
负责人:EDGAR A ARRIAGA
-
依托单位:
海外基金