Functional Microbiomics, Inflammation and Pathogenicity

项目总结/摘要 在过去的几十年里，微生物学和免疫学领域经历了一场复兴， 部分原因是技术进步确定了人类微生物组可以在许多方面发挥作用， 人类健康和疾病的基本方面，在许多情况下通过与宿主先天性 免疫力免疫系统的功能是限制由微生物群引起的潜在损害， 同时最小化破坏性炎症反应。干扰的强度，持续时间或物理 然而，炎症的位置可能导致疾病。我们对微生物组的理解的进步， 以及环境因素对其的调节，沿着的是炎症过程是 许多常见疾病，需要一个跨学科的角度，适应主机- 微生物的相互作用第二阶段Cobre的主要目标是继续发展和扩大我们的 微生物组、炎症之间界面研究的多学科专题研究中心 和致病性在一个框架内，以发展初级调查人员的职业生涯。我们召集了一个小组 具有互补专业知识和杰出潜力的初级调查员，并与这些项目合作 领导人与合格和敬业的导师。一套完整的项目将使新的连接 炎症过程和细菌致病性之间的关系，并建立基础的发展， 新的治疗剂和递送方法。我们将建立一个多学科的研究，培训， 指导和职业发展，这将促进和加速初级教师向独立教师的过渡 校外资助的地位。研究将得到功能微生物核心的支持， 免费动物设施，厌氧培养能力，微生物组测序和生物信息学， 炎症标志物，沿着整个动物成像和活体显微镜检查。行政核心将 协调活动并提供额外的生物统计支持，沿着试点项目计划，以确保 调查人员的管道。通过大学资助的中心的机构承诺将确保可持续性 专题研究计划。

Project Summary/Abstract In the past few decades, the fields of microbiology and immunology have undergone a renaissance, driven in part by technological advances establishing that the human microbiome can play a role in a number of fundamental aspects of human health and disease, in many instances through the interface with host innate immunity. The immune system functions to restrict the potential for damage caused by the microbiota while simultaneously minimizing destructive inflammatory responses. Disruption of the intensity, duration or physical location of inflammation, however, can contribute to disease. Advances in our understanding of the microbiome, and its regulation by environmental factors, along with a realization that inflammatory processes are at the core of a number of common diseases, necessitates a cross-disciplinary perspective that accommodates the host- microbe interaction in toto. The major goal of this Phase 2 Cobre is to continue to develop and expand our thematic multidisciplinary research center for the study of the interface between the microbiome, inflammation and pathogenicity within a framework to develop the careers of junior investigators. We have assembled a team of junior investigators with complementary expertise and outstanding potential, and have partnered these project leaders with well-qualified and dedicated mentors. An integrated set of projects will make novel connections between inflammatory processes and bacterial pathogenicity, and establish the basis for the development of novel therapeutics and delivery methods. We will create a multidisciplinary program in research, training, mentoring and career development that will facilitate and accelerate the transition of junior faculty to independent extramural funded status. Research will be support by a Functional Microbiomics Core that will provide germ free animal facilities, anaerobic culture capability, microbiome sequencing and bioinformatics, assay of inflammatory markers, along with whole animal imaging and intravital microscopy. An Administrative Core will co-ordinate activities and provide additional biostatistical support, along with a Pilot Project program to ensure a pipeline of investigators. Institutional commitment through a university funded Center will ensure sustainability of the thematic research program.