Pilot and Exploratory Studies Core

摘要 试点和探索性研究核心(PESC)的目标是为将开展的研究提供支持 并测试与中心总体主题高度相关的新研究想法：提高对 代谢因素和炎症与年龄相关疾病和合并症相互作用，决定关键健康 结果与活动能力和功能状态有关。因此，PESC将资助广泛的先导性研究 学科范围广泛，从基础、临床前、临床以患者为中心的研究到行为和健康 服务研究。每个提交的提案将首先接受至少三个人的科学价值评估 外聘审查员，然后由审查处领导进一步评估其与中心目标的相关性。这个 自1989年成立以来，PESC已经发放了155笔试点助学金，主要发放给初级教职员工，其中许多人现在已经 确立了自己在老年医学和相关学科中富有成效的独立研究人员的地位。 2020-2021年(竞争更新的第一年)选定了五个项目，包括：1)类型2 老年非裔美国男性的糖尿病自我管理：同行领导的试点干预；2)评估去 生物bDMARDS(生物疾病改良型抗风湿药物)在老年人中的升级 类风湿性关节炎；3)家庭送餐预防复发肝性脑病： 脑食随机对照试验；4)降级途径：确定抗生素处方的特征 对老年人来说是一连串的。5)蛋白质翻译动力学的年龄相关性改变。PESC将会是 由Lona Mody博士和Daniel Goldstein博士执导。他们将与研究教育核心密切合作 (REC)和所有资源核心(RCS)，以支持创新和有前途的项目的实施 由初级科学家或更资深的研究人员提出，增加了 项目将导致外部支持的老龄化研究。

Abstract The goal of the Pilot and Exploratory Studies Core (PESC) is to provide support for studies that will develop and test new research ideas of high relevance to the Center’s overall theme: improve understanding of how metabolic factors and inflammation interact with age-related diseases and comorbidities to determine key health outcomes related to mobility and functional status. The PESC will thus fund pilot research studies over a wide range of disciplines, from basic, pre-clinical, clinical patient-oriented research through behavioral and health services research. Each submitted proposal will first receive an evaluation for scientific merit by at least three external reviewers and then be further evaluated by OAIC leaders for relevance to the Center objectives. The PESC has made 155 pilot grants since its inception in 1989, mostly to junior faculty, many of whom have now established themselves as productive independent researchers in geriatric medicine and cognate disciplines. Five projects have been selected for 2020-2021 (Year 1 of the competing renewal), including: 1) Type 2 Diabetes Self-Management in Older African American Men: A Peer Leader Pilot Intervention; 2) Evaluate de- escalation of biologic bDMARDs (biologic disease modifying anti-rheumatic drugs) among older adults with Rheumatoid Arthritis; 3) Home-delivered meals to prevent recurrent hepatic encephalopathy: The BRAINFOOD randomized controlled trial; 4) Pathway to De-escalation: Characterizing antibiotic prescribing cascade for older adults. 5) Age-associated alterations in protein translation dynamics. The PESC will be directed by Drs. Lona Mody and Daniel Goldstein. They will work closely with the Research Education Core (REC) and all the Resource Cores (RCs) to support implementation of innovative and promising projects proposed by junior scientists, or more senior investigators new to aging research, increasing the likelihood that projects will lead to externally supported research in aging.