Training in Pediatric Nonmalignant Hematology and Stem Cell Biology

项目摘要/摘要 对儿童许多血液病的分子发病机制了解甚少。 我们开发了一项创新的、多学科的儿科非恶性肿瘤培训计划 血液学和干细胞生物学研究人员，他们拥有独特的专业知识，可以促进 多学科研究。目前，斯坦福大学没有其他项目支持 培训医学博士、医学博士或博士研究生学习儿科非恶性血液学和干细胞生物学。 鉴于这一研究领域的翻译科学家和基础科学家的数量不断减少，我们的培训计划是 对继续在该领域取得进步并保持一支专注于儿科的研究人员管道至关重要 非恶性血液学和干细胞生物学。 我们提出了一个整合了各种学科和专业知识的培训计划，包括分子 以及细胞造血、替代生物模型、干细胞移植、蛋白质组学/基因组学， 翻译研究和生物信息学。在这份修订后的续签申请中，我们增加了新的教职员工 具有新颖、尖端技术方面的专业知识；该计划在翻译方面的新方面 与硅谷的专家合作进行研究，包括制药和 生物技术产业；一名生物信息学专家和为学员开设的一门新的生物信息学课程； 新的初级教员，他们将被指导成为未来的T32教员导师。 在这项申请中，我们要求每年资助两名医学博士、医学博士或博士后研究员参加 最多两年。学员将有机会在22个已建立的研究项目中进行研究 教员导师的实验室。受训人员将从大约54名符合条件的内部人员中挑选出来 博士后研究员候选人除外部候选人外，还应根据其学术潜力、职业生涯 目标和研究成果。第二年的资金将取决于他们的进展报告。 受训人员将参加期刊俱乐部、血液学和干细胞生物学讲座、临床会议和 研究研讨会。为实习生举办的职业发展研讨会包括助学金写作、专业精神和 领导力。受训人员还将被要求参加一门儿科非恶性血液学和干细胞课程 细胞生物学、伦理学和科学诚信。实习生将与项目主任和奖学金会面 监督委员会每6个月监测进展情况，并将在国家和 国际会议。外部咨询委员会将审查该方案并与受训人员会面 每年都有。我们将利用斯坦福大学的优势，在儿科领域开展研究合作 非恶性血液学和干细胞生物学，包括研究人员的广度和深度 许多学科，以培养该领域的未来领导者。

Project Summary/Abstract Very little is understood about the molecular pathogenesis of many hematologic diseases in children. We have developed an innovative, multidisciplinary training program in pediatric nonmalignant hematology and stem cell biology with investigators who have unique expertise and can foster multidisciplinary research. Currently, there is no other program at Stanford University that supports the training of MD, MD/PhD, or PhD fellows to study Pediatric Nonmalignant Hematology and Stem Cell Biology. Given the declining number of translational and basic scientists in this area of research, our training program is critical to continue advancements in the field and maintain a pipeline of researchers focusing on pediatric nonmalignant hematology and stem cell biology. We propose a training program that integrates a variety of disciplines and expertise, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, proteomics/genomics, translational research, and bioinformatics. In this revised renewal application, we have added new faculty with expertise in novel, cutting edge technologies; new aspects of the program in translational research in collaboration with experts in Silicon Valley including those in pharmaceutical and biotechnology industries; an expert in bioinformatics and a new bioinformatic course for trainees, and new junior faculty who will be mentored to become T32 faculty mentors in the future. In this application, we seek funding for two MD, MD/PhD, or PhD postdoctoral fellows per year for a maximum of two years. Trainees will have the opportunity to develop research in one of the 22 established faculty mentor’s laboratories. Trainees will be selected from a pool of approximately 54 eligible internal postdoctoral fellow candidates in addition to external candidates based on their academic potential, career goals, and research achievements. The second year of funding will depend on their progress reports. Trainees will participate in journal clubs, hematology and stem cell biology lectures, clinic conferences, and research seminars. Career development workshops for trainees include Grant Writing, Professionalism, and Leadership. Trainees will also be required to take a course on Pediatric Nonmalignant Hematology and Stem Cell Biology and Ethics and Scientific Integrity. Trainees will meet with the Program Directors and Scholarship Oversight Committees every 6 months to monitor progress and will present their work at national and international meetings. The External Advisory Committee will review the program and meet with trainees every year. We will utilize the strengths of Stanford University to develop research collaborations in Pediatric Nonmalignant Hematology and Stem Cell Biology, including the breadth and depth of investigators across many disciplines, to train future leaders in the field.