Tri-Institutional PhD Program in Chemical Biology

项目总结 三所院校化学生物学博士项目(TPCB) 三所院校化学生物学博士项目是一项创新性的研究生项目， 为学生提供化学、生物和医学方面的综合培训。三氯二苯醚是 独特之处在于，它是由三个一流的研究机构联合提供的，毗邻的校区位于 纽约市：纪念斯隆·凯特琳癌症中心、洛克菲勒大学和威尔·康奈尔 医学院。这个独立的、直接招生的研究生课程成立于2001年，是 在全国率先专门致力于培养下一代化学生物学研究人员。 在过去的19年里，TPCB已经确立了自己作为领先的化学生物学研究生课程的地位，拥有70名学生 博士毕业生和43名在校生(26名符合培训补助金资格的TGE)。学生来自这两个化学公司 和生物学背景，该计划结合了定量的化学培训和对 生物医学研究的前沿问题。学生们也来自广泛的科学和文化领域 背景和这种多样性是值得庆祝的。该计划欢迎来自代表不足的少数族裔的学生 群体、残疾人和处于不利社会经济背景的人(目前总计 TGE的35%)，并与每个学生单独合作，以确保他们拥有成长所需的资源。 课程包括两门专门为TPCB学生开设的化学生物学课程，额外的核心课程 和选修课，研讨会课程，实验室轮换，学生研究进展研讨会，年度学生- 组织了Tri-I化学生物学研讨会和TPCB学生职业发展务虚会，以及 桑德斯三联化学生物学系列研讨会。学生接受广泛的职业发展培训，并 负责任的研究、严谨和可再现性方面的正式持续指导。学生们有 有机会与54名敬业的教师导师一起进行博士论文研究，他们的工作范围涵盖 化学生物学，平均每年资助100万美元。学生们在这三所学校之间无缝地流动 拥有最先进的研究设施和丰富的科学环境 校园，提供不同的机会从事基础和翻译研究并参与 多学科协作。重要的是，TPCB的学生深入参与了组织和设计 该计划不断地根据学生的反馈而发展。 因此，TPCB的学生非常有成效，发表了400多篇科学论文(平均 5.2篇/毕业生)，平均5.5年毕业。TPCB的校友们继续在广泛的领域工作 在终身教职(17%)、制药(12%)、生物技术(29%)、其他实验室(10%)以及 与研究相关的职业(31%)。TPCB得到了强有力的制度支持，但仍无法承认所有 符合条件的申请者。因此，这项NIGMS化学-生物接口T32培训补助金将使 进一步发展和加强这一成功的培训计划及其对社区的更广泛影响。

PROJECT SUMMARY Tri-Institutional PhD Program in Chemical Biology (TPCB) The Tri-Institutional PhD Program in Chemical Biology (TPCB) is an innovative graduate program that provides students with comprehensive training at the interface of chemistry, biology, and medicine. TPCB is unique in that it is offered jointly by three premier research institutions with adjacent campuses in the heart of New York City: Memorial Sloan Kettering Cancer Center, The Rockefeller University, and Weill Cornell Medical College. This stand-alone, direct admission graduate program was established in 2001 as one of the first in the nation to focus specifically on training the next generation of chemical biology researchers. Over the last 19 years, TPCB has established itself as a leading graduate program in chemical biology, with 70 PhD graduates and 43 current students (26 training grant-eligible, TGE). Students come from both chemical and biological backgrounds and the program combines quantitative chemical training with deep insights into forefront problems in biomedical research. Students also come from a wide range of scientific and cultural backgrounds and this diversity is celebrated. The program welcomes students from underrepresented minority groups, those with disabilities, and those from disadvantaged socioeconomic backgrounds (currently totaling 35% of TGE) and works with each student individually to ensure they have the resources necessary to thrive. The curriculum includes two chemical biology courses created specifically for TPCB students, additional core and elective courses, a seminar course, lab rotations, student Research-in-Progress seminars, annual student- organized Tri-I Chemical Biology Symposium and TPCB Student Career Development Retreat, and the Sanders Tri-I Chemical Biology Seminar Series. Students receive extensive career development training and formal ongoing instruction in Responsible Conduct of Research and Rigor & Reproducibility. Students have opportunities to conduct PhD thesis research with 54 dedicated faculty mentors working across the spectrum of chemical biology with >$1M average annual funding. Students move seamlessly between the three institutions and have access to the state-of-the-art research facilities and rich scientific environment on all three campuses, providing diverse opportunities to pursue fundamental and translational research and to engage in multidisciplinary collaborations. Importantly, TPCB students are deeply involved in the organization and design of the training experience, and the program has evolved continually in response to student feedback. As a result, TPCB students have been exceptionally productive, publishing over 400 scientific papers (average 5.2 papers/graduate), graduating in an average of 5.5 years. TPCB alumni have continued onto a wide range of successful careers across the tenure track (17%), pharma (12%), biotech (29%), other labs (10%), and research-related careers (31%). TPCB receives strong institutional support but is still unable to admit all of the qualified candidates who apply. Thus, this NIGMS Chemistry–Biology Interface T32 training grant will enable further growth and enhancement of this successful training program and its broader impacts on the community.