Animal and Animal Food Diagnostic Sample Analysis in Support of FDA Vet-LIRN Activities and Investigations

项目摘要/摘要 宾夕法尼亚大学动物诊断实验室系统(PADLS) 博尔顿中心在病理学领域提供全面的兽医诊断服务， 微生物学，分子诊断学和毒理学，完全认可的美国协会 兽医实验室诊断员(AAVLD)和兽医一级实验室成员 实验室调查和反应网络(VET-LIRN)。保护动物和公民的安全 宾夕法尼亚州联邦针对动物健康和食品安全的威胁，该实验室提供 作为美国东部的关键资源，使其非常适合VET-LIRN项目提案。 我们的实验室在各种样品和基质类型的分析方面经验丰富，包括但不是 仅限于动物样品、环境样品、害虫、水、动物药品和动物和 人类的食物产品和配料，如谷物、肉、鱼和牛奶。我们将使用我们实验室的 兽医诊断经验、专业知识和基础设施，以完成为此所述的工作 项目。除了满足在发生大规模爆炸时增加实验室能力的需求 涉及动物性食品、与药物有关的疾病或其他大规模紧急事件的爆发或事件 需要浪涌容量测试，PADLS新博尔顿中心实验室可以进一步加强 VET-LIRN通过诊断活动，更好地早期检测涉及到的新出现的事件 国家食品安全和保障，促进快速反应，最大限度地减少危害和最好的 保护人类和动物的健康。 我们的实验室为宾夕法尼亚州和 通过联邦、州和地方的合作，在周边地区开展合作。有些分析是正常的一部分 监测活动或常规尸检，而其他与过度， 意外的或无法解释的动物损失或疾病，可能会对 动物健康和/或动物或人类食品安全。实验室遵循AAVLD的《要求》 获得认可的兽医诊断实验室“，满足以下具体要求 实验室及其活动的方方面面。AAVLD还要求我们的实验室具有 记录政策、系统、计划和程序的系统。由于不同的性质， 我们收到的样本矩阵我们正在不断改进和改进我们的分析方法，以便 确保它们的敏感性和特异性。我们相信我们有能力继续支持Vet-LIRN在 这个项目归功于我们目前的资格和经验以及成功的兽医-LIRN的成熟历史 通过基础设施和方法开发拨款计划进行协作。

PROJECT SUMMARY/ABSTRACT The Pennsylvania Animal Diagnostic Laboratory System (PADLS) at the University of Pennsylvania’s New Bolton Center offers comprehensive veterinary diagnostic services in the areas of pathology, microbiology, molecular diagnostics, and toxicology, as fully accredited by the American Association of Veterinary Laboratory Diagnosticians (AAVLD) and a first-tier laboratory member of the Veterinary Laboratory Investigation and Response Network (Vet-LIRN). Safeguarding the animals and citizens of the Commonwealth of Pennsylvania against threats to animal health and food safety, the laboratory serves as a critical Eastern United States resource, making it an excellent fit for this Vet-LIRN project proposal. Our laboratory is experienced in the analysis of a variety of sample and matrix types, including but not limited to animal samples, environmental samples, vermin, water, animal drug products, and animal and human food products and ingredients such as grain, meat, fish, and milk. We will use our laboratory’s veterinary diagnostic experience, expertise, and infrastructure to accomplish the work described for this project. In addition to addressing the need for added laboratory capacity in the event of a large-scale outbreak or incident involving animal food, drug-related illnesses, or other large-scale emergency events requiring surge capacity testing, the PADLS New Bolton Center Laboratory can further strengthen the Vet-LIRN through diagnostic activities that better enable early detection of emerging events involving national food safety and security and facilitate the rapid responses that can minimize harm and best protect both human and animal health. Our laboratory provides comprehensive veterinary diagnostic services to the Pennsylvania and the surrounding region through federal, state, and local collaborations. Some analyses are part of normal surveillance activities or routine necropsies, while others are associated with cases of excessive, unexpected, or otherwise unexplainable animal losses or illness that may potentially pose a risk to animal health and/or animal or human food safety. The laboratory adheres to AAVLD’s “Requirements for an Accredited Veterinary Medical Diagnostic Laboratory”, meeting specific requirements pertaining to all aspects of the laboratory and its activities. AAVLD also requires that our laboratory has a Quality System that documents policies, systems, programs, and procedures. Due to the varied nature of the sample matrices we receive we are constantly improving and refining our analytical methods in order to ensure their sensitivity and specificity. We are confident in our ability to continue to support Vet-LIRN in this project due to our present qualifications and experience and a proven history of successful Vet-LIRN collaborations through both the infrastructure and method development grant programs.