MGH Next Generation Physician-Scientist Through Stimulating Access to Research in Residency Program (MGH-Next Gen StARR)

项目总结 医生-科学家在弥合基础科学和临床医生之间的鸿沟方面发挥着独特的作用 确定重要的临床问题并将结果转化为改善患者护理的方法。不幸的是， 医生-科学家队伍继续减少，并在 生物医学研究。许多住院医师计划主要侧重于获取医学知识，而不是 培养求知欲和生物医学研究领域的入门知识。在这项建议中，我们的目标是 在住院医师培训期间，增强作为内科科学家职业的吸引力和准备。 进一步削弱人们对内科科学家职业兴趣的是找出一个鼓舞人心的 也是成功的导师。迫切需要重新重视公认的内科科学家，如 实习生的榜样。心脏生物学、肺部炎症和再生医学是基础 从强大的医生-科学家队伍中受益匪浅的科学领域。我们假设早些时候 纵向指导与该领域的研究和专业发展技能的发展相结合 再生医学、心脏和肺部生物学将使医生-科学家的职业道路更具吸引力 而且是可持续的。为此，我们建议下一步实施马萨诸塞州综合医院- 通过刺激住院研究(MGH下一代)实现新一代医生-科学家 Starr)计划。该计划将在整个生物医学研究过程中培训新的内科科学家 世卫组织将促进针对心脏、肺和血液疾病的新的预防和治疗措施。这个 MGH下一代STARR计划围绕以下三个目标：[1]促进 通过强调领导力的强有力的纵向指导做出重要的科学贡献 基本要素；[2]开发足够的基本实验室和必要的翻译方法，以进行高- 再生医学、心脏代谢和肺部生物学领域的高质量研究；以及 阐述基于假设的研究问题、研究项目的开发和执行，以及 有效地传播他们的科学的意义。MGH下一代Starr计划将允许两名居民 从医学系毕业，在麻省理工学院或博德研究所进行为期12-24个月的研究。这个 该计划将由Jatin M Vyas(医学)、执行指导委员会和外部咨询委员会领导， 以及58名多学科、资金充足的研究导师。总而言之，这些倡议旨在 在血管生物学和再生领域的生物医学研究中吸引、培训和留住医学博士 医生处在他们职业生涯最关键的关头--住院医师培训。

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Unfortunately, the physician-scientist workforce continues to diminish and contributes to negative, long-lasting consequences in biomedical research. Many residency programs focus heavily on acquiring medical knowledge as opposed to fostering intellectual curiosity and an introduction into the biomedical research field. In this proposal, we aim to enhance attractiveness and preparedness for a career as a physician-scientist during residency training. Furthering the diminishing interest in a career as a physician-scientist is the ability to identify an encouraging and successful mentor. There is a critical need for a renewed emphasis on established physician-scientists as role models to trainees. Cardiac biology, pulmonary inflammation and regenerative medicine are fundamental areas of science that greatly benefits from a robust physician-scientist workforce. We hypothesize that early and longitudinal mentorship combined with development of research and professional development skills in the areas of regenerative medicine, cardiac and pulmonary biology will make the physician-scientist career path attractive and sustainable. To this end, we propose the implementation of the Massachusetts General Hospital Next- Generation Physician-Scientist Through Stimulating Access to Research in Residency (MGH Next-Gen StARR) program. The program will train new physician-scientists throughout the biomedical research continuum who will promote new preventative and therapeutic measures for diseases of the heart, lungs, and blood. The MGH Next-Gen StARR program is centered around the following three objectives: [1] To foster the creation of important scientific contributions through strong, longitudinal mentorship with an emphasis on leadership essentials; [2] To develop sufficient basic laboratory and translational approaches necessary to conduct high- quality research in the areas of regenerative medicine, cardiometabolic and pulmonary biology; and [3] To formulate hypothesis-based research questions, development and execution of a research project, and effectively communicate the significance of their science. MGH Next-Gen StARR program will allow two residents from the Department of Medicine to conduct research for 12-24 months at MGH or the Broad Institute. The program will be led by Jatin M Vyas (Medicine), an Executive Steering Committee and External Advisory Board, along with 58 multidisciplinary and well-funded research preceptors. Together, these initiatives are designed to attract, train, and retain MDs in biomedical investigation in the areas of vascular biology and regenerative medicine at the most critical juncture of their career - residency training.