Core B: Neuroimaging Core

项目摘要-神经成像核心-核心B 神经成像核心将为加州大学戴维斯分校对抗中心的调查人员提供 快速发展的神经成像技术领域，这三个科学领域都有强烈的需求 项目。神经成像工具提供了最好的现代手段之一，以检查病理生理学 影响大脑的紊乱。研究中心的研究人员此前已经展示了神经成像的好处 急性有机磷农药中毒的短期和长期后果评估技术 并确定有效的治疗策略，以减轻由此产生的神经病理。这个 神经成像核心公司将利用这些以前的成功，为 神经成像横跨显微到整个大脑的活体成像，以及在图像采集方面的专业知识， 分析、开发和验证成像生物标记物，以支持科学项目。这个 提供的神经成像资源将包括侧重于结构神经成像的方式，如磁学 磁共振成像(MRI)和X射线计算机断层扫描(CT)、功能和分子成像，如MRI 和正电子发射断层扫描(PET)，以及相关的细胞高含量亮场和荧光组织 成像。神经成像核心的监督和管理将由核心领导Abhijit Chaudhari提供， 博士，放射学教授，加州大学戴维斯分校分子和基因组成像中心主任 (CMGI)，在动物和人体成像方面拥有超过15年的各种成像方式的经验， 定量成像科学、成像生物标记物设计和验证以及医学图像处理； 共同领导，布拉德·霍布森博士，CMGI研究科学家，曾接受过广泛的神经毒理学培训， 有机磷背景下的药理学和体内外神经成像方法的验证 曝光。神经成像核心的目标是：(1)为中心调查人员提供访问 广泛的神经成像技术，从细胞成像到宏观的活体结构， 功能成像和分子成像，以追求项目的科学目标；(2)开发和部署 先进的成像技术将加强中心调查人员的研究努力；以及(3) 为中心的研究教育使命提供虚拟和实践培训，以利用 成像方法、数据采集和图像分析。通过提供神经成像专业知识，核心将 确保设计、实施和分析加州大学戴维斯中心调查人员的成像研究 严格确保对人类的透明性、再现性和未来的可译性。

Project Summary – Neuroimaging Core – Core B The Neuroimaging Core will provide UC Davis CounterACT Center investigators with outstanding resources in the rapidly evolving field of neuroimaging technologies, for which there is strong demand by all three scientific Projects. Neuroimaging tools provide one of the best modern means for examining the pathophysiology of disorders that affect the brain. Center investigators have previously shown the benefits of neuroimaging technologies for evaluating the short- and long-term consequences of acute organophosphate intoxication on the brain and identifying effective therapeutic strategies that mitigate the resulting neuropathology. The Neuroimaging Core will capitalize on these previous successes and provide state-of-the-art equipment for neuroimaging spanning microscopic to whole brain in vivo imaging, and dedicated expertise in image acquisition, analysis and the development and validation of imaging biomarkers to support the scientific Projects. The neuroimaging resources provided will include modalities focused on structural neuroimaging, such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT), functional and molecular imaging, such as MRI and positron emission tomography (PET), and correlative cellular high-content brightfield and fluorescence tissue imaging. Oversight and management of the Neuroimaging Core will be provided by Core Lead, Abhijit Chaudhari, PhD, Professor of Radiology and the Director of the UC Davis Center for Molecular and Genomic Imaging (CMGI), with over 15 years of experience in animal and human imaging with various imaging modalities, quantitative imaging science, imaging biomarker design and validation and medical image processing; and Core Co-Lead, Brad Hobson, PhD, Research Scientist at the CMGI, who has extensive training in neurotoxicology, pharmacology and the validation of ex vivo and in vivo neuroimaging methods in the context of organophosphate exposure. The objectives of the Neuroimaging Core are to: (1) provide Center investigators with access to a wide array of neuroimaging technologies ranging from cellular imaging to macroscopic in vivo structural, functional, and molecular imaging in pursuit of the scientific aims of the Projects; (2) develop and deploy advanced imaging technologies that will enhance Center investigators’ research endeavors.; and (3) contribute to the research education mission of the Center by providing virtual and hands-on training in the utilization of imaging methods, data acquisition, and image analysis. By providing neuroimaging expertise, the Core will ensure that imaging studies by the UC Davis Center investigators are designed, implemented, and analyzed rigorously to ensure transparency, reproducibility and future translatability to humans.