P30 Wilmer Core Grant for Vision Research

项目总结 威尔默眼科研究所是视觉研究的世界领先者之一。我们的研究项目范围 从对眼睛发育和视力机制的基础/基础研究，到对 眼病的遗传学和发病机制，转译研究，临床试验，流行病学 以及全球范围内导致视力丧失和残疾的原因的国际研究。威尔默一直在 幸运的是，通过NEI视觉研究核心助学金获得了超过45 几年来，这笔资金为这些项目提供了基础设施和核心支持 学习。核心赠款提供的支持不仅在以下方面提供了巨大的帮助 促进威尔默的多样化研究计划并鼓励众多合作研究 这不仅是一项重要的项目，而且也有助于培训许多未来的视觉科学家。在这 竞争续订申请，我们正在寻求支持以继续这些基本的基础设施和 核心活动。我们既建议继续过去的服务，也建议修改和更新 一些核心，以便更好地适应不断变化的研究需求、技术和优先事项。这个 申请资助的模块包括成像和显微镜、生物统计学、 生物信息学、动物模型、药物输送和纳米技术。我们觉得这个模块 结构，加上严格的行政支助结构，将最好地服务和促进 威尔默和整个约翰霍普金斯大学的各种视觉研究和培训活动。

PROJECT SUMMARY The Wilmer Eye Institute is one of the world leaders in vision research. Our research programs range from basic/fundamental studies on the mechanisms of eye development and vision, to studies of the genetics and pathogenesis of eye disease, to translational studies, to clinical trials, to epidemiological and international studies of the worldwide causes of vision loss and disability. Wilmer has been fortunate to have been funded through an NEI Core Grant for Vision Research for over forty five years, and this funding has provided the infrastructure and core support for a wide variety of these studies. The support that the Core grant has provided has not only been a tremendous aid in facilitating Wilmer's diverse research programs and encouraging numerous collaborative research projects, but it has also helped in making possible the training of many future vision scientists. In this competitive renewal application, we are seeking support to continue these essential infrastructure and core activities. We are proposing both continuation of past services, but also modifying and updating some cores so as to better adapt to changing research needs, technologies, and priorities. The modules for which funding is requested are cores for Imaging and Microscopy, Biostatistics, Bioinformatics, Animal Modeling, and Drug Delivery and Nanotechnology. We feel that this module structure, together with a rigorous administration support structure, will best serve and facilitate the diverse vision research and training activities at Wilmer and throughout Johns Hopkins.