Miami Clinical and Translational Science Institute

项目摘要 位于南佛罗里达州(SoFL)的迈阿密大学临床和转化科学研究所的目标是 (CTSI)是为了改善我们社区的健康，解决健康差距，并促进健康公平。这个 CTSI通过催化开发、示范和传播 科学和运营创新，提高临床和医疗服务的效率、效果和质量 翻译研究。这是通过不同利益攸关方的双向参与来完成的，包括 患者权益倡导者和社区合作者，帮助确定 翻译研究过程。作为回应，CTSI开发和测试利益相关者驱动的资源、工具、 和干预措施，最终促进采用和整合那些被证明是 通过传播和执行努力取得成功。这项工作由三个主要因素决定： 1)SoFL的特点是种族、民族、语言、 移民身份、社会经济劣势和污名化。这种复杂性使CTSI集线器 研究人员探索在其他地方难以概念化和评估的研究问题；2)CTSI 在其科学队伍和研究中优先考虑多样性、公平性、包容性和可及性(DEIA) 参与者；以及3)CTSI拥有强大、成功和持续的真实社区记录和 利益相关者参与，促进多学科研究，成功克服 复制现有不平等的翻译陷阱。CTSI的重点、活动范围和目标是 基于对这些因素及其相互之间的复杂相互作用的理解。与.一起 不同的利益攸关方，CTSI将：1)支持创新资源的开发和传播以及 提高整个翻译行业的研究质量、效率和效果的服务 研究范围；2)促进研究合作，旨在促进和加速研究 改善社区卫生，解决卫生差距，促进卫生公平；3)发展创新 培训计划，以支持团队科学为导向的CTS员工，从翻译科学家到临床 研究专业人员和主要利益攸关方；以及4)支持CTS研究，以响应这些首要问题 目标。通过这些努力，CTSI预计将在质量、安全、 其临床和转译企业的效率、有效性和信息性。然后，CTSI将 在区域和全国范围内广泛传播其获得的知识，以最大限度地发挥影响和机会 无论是现在还是将来。通过这样做，CTSI加速了带来翻译科学的好处(更多 有效的治疗、药物、设备、行为干预和医疗程序)给所有人， 无论他们的身份或访问权限如何。 PHS 398/2590(06/09版)页面续格式页面

Project Summary Located in South Florida (SoFL), the goals of University of Miami’s Clinical and Translational Science Institute (CTSI) are to improve the health of our community, address health disparities, and promote health equity. The CTSI accomplishes these goals by catalyzing the development, demonstration, and dissemination of scientific and operational innovations that improve the efficiency, effectiveness, and quality of clinical and translational research. This is done through bidirectional engagement of diverse stakeholders, including patient advocates and community collaborators, to help identify gaps, challenges, and chokepoints in the translational research process. In response, the CTSI develops and test stakeholder-driven resources, tools, and interventions ultimately promoting the adoption and integration of those that are demonstrated to be successful, through dissemination and implementation efforts. This work is shaped by three primary factors: 1) SoFL is characterized by complex and multifaceted diversity with respect to race, ethnicity, language, immigrant status, socioeconomic disadvantage, and stigmatization. This complexity allows CTSI Hub investigators to explore research questions difficult to conceptualize and evaluate elsewhere; 2) CTSI prioritizes diversity, equity, inclusion, and accessibility (DEIA) in its scientific workforce and research participants; and 3) CTSI has a strong, successful and sustained record of authentic community and stakeholder engagement which facilitates multidisciplinary research that can successfully overcome the translational pitfall of replicating existing inequities. The CTSI’s focus, scope of activities and aims are grounded in an understanding of these factors and their complex interplay with one another. Together with diverse stakeholders, the CTSI will: 1) support the development and dissemination of innovative resources and services to increase the quality, efficiency, and effectiveness of research across the entire translational research spectrum; 2) promote research collaborations aimed at facilitating and accelerating research to improve community health, address health disparities, and promote health equity; 3) develop innovative training programs to support a team science-oriented CTS workforce, from translational scientists to clinical research professionals and key stakeholders; and 4) support CTS research responsive to these overarching goals. Through these efforts, the CTSI expects to achieve significant improvements in the quality, safety, efficiency, effectiveness, and informativeness of its Clinical and Translational Enterprise. The CTSI will then broadly disseminate its acquired knowledge regionally and nationally to maximize impact and opportunity, both now and in the future. By doing so, the CTSI accelerates bringing the benefits of translational science (more effective treatments, drugs, devices, behavioral interventions, and medical procedures) to all people, regardless of their identity or access. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page