Core A -- Administrative Core

抽象行政核心 行政核心的职责包括全面领导MIDUS以及监督数据 研究数据的收集、管理和交付。领导将由校长提供 调查员(PI)和执行指导委员会(ESC)，由以下机构的领导人/共同领导人组成 项目和核心。他们将监督有关执行和完成规定的重大决策 U19和辅助AD/ADRD U01应用程序的目标。主要领导任务包括：监测 在实现研究的资助目标方面取得进展；培养有效和协同的沟通 跨项目和核心；组织和主持联合调查员、公众用户和 数据监测委员会(DMC)；确保研究执行过程中的质量控制；管理合同 协定、资金分配和年度报告；以及在需要时解决争端。日常工作 职责由UW-Madison的行政核心联合领导集中管理，包括协调 跨项目收集数据。本U19包括四个项目(调查、每日、Biomarker、基因组学) 辅助AD/ADRD U01中包括三个项目(认知、情感神经科学、ADRD 神经科学)。将收集所有人的数据(在6年内)，涵盖下一波更新 (MR2)和核心(M4)国家样本以及来自密尔沃基的目标非洲裔美国人样本。这个 管理核心将监督和处理这项复杂的任务，这需要仔细排序从 项目之间的沟通，以及特定于项目的调查人员之间的及时沟通。这些目标将 通过管理答复者的创新在线管理核心数据库系统实现 跨项目实时分配、参与和联系信息。管理核心还将创建 并向研究界提供具有全面、用户友好的文档的高质量数据集。 这些目标将通过元数据约定和使用由 研究文档标准称为数据文档倡议(DDI)。在这些努力的基础上， 管理核心将继续增强一个独一无二的在线门户，帮助用户进行智能搜索 函数、协调工具和定制数据提取，从而支持纵向和 MIDUS的生物、心理和社会综合目标。敏感数据(例如来自基因组学和神经科学的数据 项目)将通过受限访问程序和由管理员管理的存储库提供 核心。管理核心联合领导人将通过以下演示和网络研讨会促进公众使用MIDUS数据集 描述如何访问和使用NACDA和门户数据。最后，管理核心将监督和 管理与MIDUS的外部数据资源的链接，如定期死亡率更新、医疗保险记录、 MIDUS参与者的地理编码、用药情况和职业描述。

ABSTRACT – ADMINISTRATIVE CORE The Administrative Core’s responsibilities include overall leadership of MIDUS as well as oversight of data collection, management, and delivery of research data. Leadership will be provided by the Principal Investigator (PI) and Executive Steering Committee (ESC), consisting of the Leaders/Co-Leaders of the Projects and Cores. They will oversee major decisions regarding implementation and completion of the stated aims of the U19 and the Ancillary AD/ADRD U01 applications. Primary leadership tasks include: monitoring progress in achieving funded objectives of the research; nurturing effective and synergistic communication across Projects and Cores; organizing and hosting meetings among co-investigators, public users, and the Data Monitoring Committee (DMC); insuring quality control in execution of the research; managing contractual agreements, allocation of funds, and yearly reporting; and resolving disputes, when needed. Day-to-day responsibilities are centrally managed by Admin Core Co-Leaders at UW-Madison, including coordination of data collection across Projects. Four Projects are included in this U19 (Survey, Daily, Biomarker, Genomics) and three Projects are included in the Ancillary AD/ADRD U01 (Cognitive, Affective Neuroscience, ADRD Neuroscience). Data for all will be collected (over a 6-year period) that covers the next wave of the Refresher (MR2) and the Core (M4) national samples as well as targeted African American samples from Milwaukee. The Admin Core will oversee and field this complex task, which requires careful sequencing of recruitment from Project to Project, combined with timely communication among Project-specific investigators. Such goals will be accomplished through an innovative online Administrative Core database system that manages respondent assignment, participation, and contact information across Projects in real-time. The Admin Core will also create and deliver to the research community high quality datasets with comprehensive, user-friendly documentation. These goals will be advanced via metadata conventions and use of cutting-edge technology supported by a research documentation standard called the Data Documentation Initiative (DDI). Building off these efforts, the Admin Core will continue to enhance a one-of-a-kind online Portal that aids users with intelligent search functions, harmonization tools, and custom data extracts, thereby supporting the longitudinal and biopsychosocial integrative objectives of MIDUS. Sensitive data (such as from Genomics and Neuroscience Projects) will be made available via restricted access procedures and repositories managed by the Admin Core. Admin Core Co-Leaders will facilitate public use of MIDUS datasets via presentations and webinars that describe how to access and work with the NACDA and Portal data. Finally, the Admin Core will oversee and manage linkages to external data resources to MIDUS, such as regular mortality updates, Medicare records, geo-coding, medication usage, and occupational descriptors of MIDUS participants.