Molecular Analysis, Modeling and Correction of Skin Diseases

描述(申请人提供)：这是一项建立科罗拉多大学-丹佛皮肤病研究核心中心(UCD-SDRC)的新提案。该中心将强调了解人类自身免疫、炎症、发育、代谢和遗传性皮肤病的分子基础，以及开发在遗传和表型水平上模拟这些疾病的基因工程小鼠模型。这些小鼠模型将被用于开发新的治疗方法，例如基于干细胞的治疗。该中心包括49名研究人员，其中15人来自皮肤科，34人来自UCD其他科室或与UCD合作的其他地点。这些研究人员的研究兴趣广泛：炎症和免疫、上皮生物学、黑素细胞生物学、再生医学和干细胞生物学、分子细胞和发育生物学、生物化学、药理学、微生物学和病毒学、遗传学和基因组学、组织修复、皮肤致癌和临床研究。这是基础研究和转化性研究中跨学科发现的丰富平台。这项建议有四个具体目标：1.提供核心设施，作为基础和翻译研究中跨学科发现的平台，管理核心、分子遗传分析核心、转基因和基因靶向核心、形态和表型核心，以及流式细胞术核心：2组织一个强有力的试点和可行性计划，以吸引新的研究人员(年轻的和成熟的)进入皮肤和皮肤病的研究。本申请包括六个新的P&F项目，以及用于选择未来项目的结构；3为UCD-SDRC组织一个丰富计划；4组建一个临床研究团队，以促进基于核心和P&F研究支持的基础研究发现的转化性研究项目的开发。UCD-SDRC的长期目标是通过协调和培养各种非常成功的基础科学和临床研究人员进行多学科研究、培训和临床护理，为皮肤生物学、病理生物学和临床皮肤病学提供新的方法和见解。

DESCRIPTION (provided by applicant): This is a new proposal to establish the University of Colorado-Denver Skin Diseases Research Core Center (UCD-SDRC). This center will emphasize understanding the molecular basis of human autoimmune, inflammatory, developmental, metabolic and genetic skin diseases and development of genetically engineered mouse models which mimic these disorders at both the genetic and phenoty pic levels. These mouse models will be utilized for the development of new therapeutic approaches, such as stem cell-based treatments. This Center includes 49 investigators, 15 from within the Department of Dermatology and 34 from other UCD Departments or from other sites collaborating with UCD. The research interests of these investigators are broad: Inflammation and immunity, epithelial biology, melanocyte biology, regenerative medicine and stem cell biology, molecular cellular and developmental biology, biochemistry, pharmacology, microbiology and virology, genetics and genomics, tissue repair, cutaneous carcinogensis, and clinical research. This is a rich platform for interdisciplinary discovery in basic and translational research. This proposal has four Specific Aims: 1. To provide Core facilities as a platform for interdisciplinary discovery in basic and translational research, an Administrative Core, Molecular Genetic Analysis Core, Transgenic and Gene Targeting Core, Morphology and Phenotyping Core, and a Flow Cytometry Core: 2 To organize a robust Pilot and Feasibility program to attract new investigators (young, as well as, established) into research in the skin and skin disease. Six new P&F projects are included in this application, as well as a structure for selection of future projects; 3 To organize an Enrichment Program for the UCD-SDRC; 4 To assemble a Clinical Investigations Team to facilitate development of translational research projects based on the basic research discoveries supported by the cores and P&F studies. The long-term goal of the UCD-SDRC is to provide opportunities for novel approaches and insights into cutaneous biology, pathobiology and clinical dermatology through coordinating and nurturing multidisciplinary research, training, and clinical care among a variety of highly successful basic science and clinical investigators.