Simultaneous Imaging of Tissue Biochemistry and Metabolism associated with Biomechanics in Patella Femoral Joint Osteoarthritis

摘要 这份促进健康相关研究多样性的补编的总体目标是提供 培训和支持一位有前途的有抱负的科学家(Hector Carbajal Mendez先生，博士生#年 生物工程)在创新和富有成效的研究环境中。Carbajal Mendez先生是一位杰出的 对使用IMU更好地理解接头载荷感兴趣的工程师。这种兴趣直接与 我的实验室专注于膝骨性关节炎(OA)患者的关节健康。具体地说，髌股关节骨性关节炎 是疼痛和功能障碍的主要来源。已经提出了一个关于骨性关节炎发病机制的假想模型 重复的关节负荷导致骨重建的初始增加，这与血管的增加有关。 侵袭软骨深层。新兴的质子发射层析成像和磁共振 同步成像系统(PET-MRI)提供了一种令人兴奋的新方式，可以同时获取大量 功能测量以及高分辨率的形态来研究这一复杂的现象。联合加载是 目前，与骨性关节炎进展相关的生物力学因素知之甚少。 PFJOA进展情况。因此，我们的总体目标是：(1)确定横截面和纵向局部图案 和(Ii)确定步态生物力学的中介作用 和骨形态对PFJOA进展的影响。我们将进行纵向队列研究，调查100名 患有孤立性PFJOA的患者，随访2个时间点。同步的PET-MRI和步态生物力学将是 在基线和2年的随访中收集所有受试者的数据。目的1：研究横断面关系 骨和软骨成像生物标志物之间的关系，并研究相互作用的模式是如何 以步态生物力学和骨骼形态为中介。 假设1：PFJOA受试者升高的SUV将与T1、ρ和T2松弛的延长共同定位 泰晤士报。异常步态引起的负荷变化所介导的复杂的骨-软骨相互作用 生物力学和骨骼形态将显示骨和软骨之间的非共定位联系。 目的2：研究骨和软骨影像生物标志物之间的纵向关系 研究步态生物力学和形态是如何调节相互作用模式的： 假设2：早期骨代谢活动的改变(SUV)是软骨成分改变的先兆 (T1ρ和T2)。有特殊异常步态生物力学和骨骼形状特征的受试者将表现为加速 构成上的变化。目的3：确定骨-软骨相互作用预测能力 结构性和症状性PFJOA进展的纵向轨迹。假设3：两个地方都在同一地点 而由关节生物力学和骨形状介导的非共定位骨-软骨相互作用模式将是 结构性和症状性PJOA进展的重要预测因子。

ABSTRACT The overall goal of this Supplement to Promote Diversity in Health-Related Research is to provide training and support to a promising aspiring scientist (Mr. Hector Carbajal Mendez, PhD student in Bioengineering) in an innovative and productive research environment. Mr. Carbajal Mendez is a brilliant engineer with interests in using IMU’s to better understand joint loading. This interest directly align with my labs focus on joint health in subjects with knee osteoarthritis (OA). Specifically, patellofemoral joint OA is a major source of pain and dysfunction. A hypothetical model for OA pathogenesis has been proposed whereby repetitive joint loading causes an initial increase in bone remodeling, which is associated with increased vascular invasion of the deep layers of cartilage. Emerging Proton Emission Tomography and Magnetic Resonance Imaging simultaneous systems (PET-MRI) offer an exciting new modality to simultaneously acquire numerous functional measures as well as high-resolution morphology to study this complex phenomenon. Joint loading is integral to OA progression yet currently, very little is known regarding the biomechanical factors associated with PFJOA progression. Therefore, our overall goal is to: (i) identify cross-sectional and longitudinal local patterns of cartilage and bone interactions unique to PFJOA, and (ii) determine the mediation effects of gait biomechanics and bone morphology on PFJOA progression. We will conduct a longitudinal cohort study investigating 100 people with isolated PFJOA, followed for 2 time points. Simultaneous PET-MRI and gait biomechanics will be collected for all subjects at baseline and 2-year follow-up. Aim 1: To study the cross-sectional relationships between bone and cartilage imaging biomarkers and to investigate how the patterns of interactions are mediated by gait biomechanics and bone morphology. Hypothesis 1: Elevated SUV in subjects with PFJOA will be colocalized with prolongation of T1ρ and T2 relaxation times. Complex bone-cartilage interactions mediated by change in loading as a result of abnormal gait biomechanics and bone morphology will show non-colocalized associations between bone and cartilage. Aim 2: To study the longitudinal relationships between bone and cartilage imaging biomarkers and to investigate how the patterns of interactions are mediated by gait biomechanics and morphology: Hypothesis 2: Early changes in bone metabolic activity (SUV) are a precursor to cartilage compositional changes (T1ρ and T2). Subjects with specific abnormal gait biomechanics and bone shape features will show accelerated compositional changes. Aim 3: To determine the ability of bone-cartilage interactions to predict longitudinal trajectories of structural and symptomatic PFJOA progression. Hypothesis 3: Both colocalized and non-colocalized bone-cartilage interaction patterns mediated by joint biomechanics and bone shape will be significant predictors of structural and symptomatic PJOA progression.