Scientific Information Management and Literature-Based Evaluations for the DTT - Support for Scoping Activities on Specific Test Agents

范围审查涉及对文献的总结和分类，通过系统地搜索、选择和展示现有知识，快速绘制与特定研究领域相关的关键概念、证据类型和数据缺口。范围界定审查可以作为一项独立的产品进行，也可以用于支持决策，可能涉及对现有知识进行不同程度的综合。系统性综述方法和OHAT系统性综述和证据整合方法还包括术语范围界定和问题形成，作为系统性综述决策和规划过程的一部分。范围界定是一个过程，即获取关于正在审议的主题的初步背景知识，并寻求利益攸关方和客户的投入，以了解对评价主题或提名的兴趣程度，评估开展评价的潜在影响，并确定可能已经在进行的相关活动。问题形成是指系统评价过程的第一步，即明确定义或声明评估中要评价的内容以及如何评价。目前正在进行一些针对具体测试剂的范围界定活动，包括沥青、α-蒎烯、有机卤素阻燃剂。关键词：范围界定、毒理学、流行病学、接触、癌症、非癌症效应。

Scoping reviews involve the summarization and categorization of literature prepared to rapidly map the key concepts, types of evidence, and data gaps related to a defined research area by systematically searching, selecting, and presenting existing knowledge. A scoping review can be undertaken as a standalone product or in support of decision-making and may involve varying degrees of synthesis of the existing knowledge. Systematic review methodology and the OHAT Approach to Systematic Review and Evidence Integration also include the terms scoping and problem formulation as part of the decision-making and planning process for a systematic review. Scoping is the process of taking the initial background knowledge on a topic under consideration and seeking input from stakeholders and clients to understand the extent of interest in an evaluation topic or nomination, assessing the potential impact of conducting an evaluation, and identifying related activities that may already be underway. Problem formulation refers to the first step in the systematic review process in which an explicit definition or statement is reached on what is to be evaluated in the assessment and how it is to be evaluated. A number of scoping activities focused on specific test agents are in progress, including asphalt, alpha pinene, organohalogen flame retardants. Keywords: scoping, toxicology, epidemiology, exposure, cancer, non-cancer effects.