Mentoring the Next Generation of Geriatric Oncology and Supportive Care Researchers in Patient-Oriented Research to Improve the Care of Older Adults with Cancer

摘要 我有两个总体的职业目标，这两个目标与本提案的目标直接一致：1)培养高质量的患者- 以老年肿瘤学和支持性护理干预措施之间的关系为导向的研究，产生关键的 需要证据，以便通过使用新的基础设施来告知和改善老年癌症患者的护理 在希望之城的癌症和老龄化中心和国家癌症和老龄化研究小组的支持下 (CAG)，这两个项目都由我领导；以及2)指导下一代老年肿瘤学和支持性护理学者 以及未来以患者为导向的研究领导者，基于新创建的基础设施，以确保健康的 在老龄化和癌症方面训练有素的研究人员准备维持这一领域。这一点很重要，因为三分之一的人 60岁以上的美国人将在有生之年被诊断为癌症。从2010年到2030年，癌症发病率为 预计在≥65岁的人群中，癌症发病率将上升67%，这将使癌症成为一种老年病。Arti Hurria博士，我的亲密同事 我从她那里继承了这一奖项，将她的职业生涯献给了开发和验证CAG老年评估 (GA)，并开展循证研究，展示GA指导的护理以患者为中心的积极成果。我 我正在实现她的愿景，随着她的死亡而被打断。尽管GA现在被认为是护理的标准，但只有20%的 老年癌症患者在社区环境中接受GA。这次K24续订的目标是在职业生涯中期 以患者为中心的研究人员奖是：1)联合老年病学、肿瘤学和支持性研究领域 通过构建和维护基础设施来为老年肿瘤科提供公平的以患者为中心的护理 人口，2)指导下一代老年肿瘤学和支持性护理研究人员和未来 使用这一基础设施的领导者。此应用程序中提出了三个组件。第一个是一个 全面的辅导计划，以促进不同背景的学员的职业发展 教授以病人为中心的老年肿瘤学和支持性护理的研究技能。这包括开发 个性化的职业发展计划，使每个学员能够学习以病人为中心的技能 研究；1：1导师-学员会议；以及促进学员职业发展的研讨会和课程。这个 第二个组成部分是利用最近收到的基础设施赠款(NIA R33赠款，Ring Tide Foundation Goto Grant，PI：W.Dale)支持开展以患者为中心的研究，重点是改善老年人的护理 患有癌症的成年人。第三个部分是我自己的职业发展计划，其中将包括扩大最近 通过利用新开发的基础设施和扩展我的 通过1：1辅导获得国家老龄奖学金的技能集。中建议的研究、指导和培训 这项申请解决了由国家老龄研究所、国家癌症研究所、 医学研究所和美国临床肿瘤学会共同改善对老年人的护理 癌症。

ABSTRACT I have two overall career goals, which directly align with the aims of this proposal: 1) to generate high quality patient- oriented research at the nexus of geriatric oncology and supportive care interventions, generating the critically needed evidence to inform and improve the care of older adults with cancer through the use of new infrastructure underlying the City of Hope’s Center for Cancer and Aging and the national Cancer and Aging Research Group (CARG), both of which I lead; and 2) to mentor the next generation of geriatric oncology and supportive care scholars and future leaders in patient-oriented research based on newly-created infrastructure to ensure a healthy cadre of well-trained researchers in aging and cancer poised to sustain the field. This is important because one in three Americans over the age of 60 will be diagnosed with cancer in their lifetime. From 2010 to 2030, cancer incidence is expected to rise 67% for individuals age ≥ 65, making cancer a disease of aging. Dr. Arti Hurria, my close colleague from whom I inherited this award, dedicated her career to developing and validating the CARG Geriatric Assessment (GA) and conducting evidence-based research showing the positive patient-centered outcomes of GA-guided care. I am carrying out her vision cut short with her death. Although GA is now considered the standard of care, only 20% of older patients with cancer receive a GA in the community setting. The goal of this K24 Renewal for the Midcareer Investigator Award in Patient-Oriented Research is to: 1) unite the fields of geriatrics, oncology, and supportive care by building and sustaining the infrastructure to provide equitable patient-centered care for an aging oncology population, and 2) mentor the next generation of geriatric oncology and supportive care investigators and future leaders using this infrastructure. There are three components proposed in this application. The first is a comprehensive mentoring program to foster the career development of trainees from diverse backgrounds by teaching patient-oriented research skills for geriatric oncology and supportive care. This includes the development of an individualized career development plan that will enable each mentee to learn the skills of patient-oriented research; 1:1 mentor-mentee meetings; and seminars and coursework to foster mentees’ career development. The second component is to leverage the recently received infrastructure grants (NIA R33 grant, Rising Tide Foundation GOTO Grant, PI: W. Dale) to support the conduct of patient-oriented research focused on improving the care of older adults with cancer. The third component is my own career development plan, which will include expanding recent interventional and implementation work’s impact by leveraging newly developed infrastructure, and expanding my skill set in national aging scholarship through 1:1 mentoring. The research, mentorship, and training proposed in this application address key priorities identified by the National Institute of Aging, National Cancer Institute, Institute of Medicine, and American Society of Clinical Oncology to improve the care of older adults with cancer.