CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。哥伦比亚大学医学中心(CUMC)的CTSA计划将改变临床和转化(C/T)研究的文化，使我们能够培养和留住一支优秀的高级教员队伍，以领导下一代C/T研究人员。在CUMC-Herbert Irving捐赠基金的大力支持下，我们将通过创建欧文临床和翻译研究所(IfCTR)来实现我们的目标。该捐赠基金将从目前的1500万美元增加到2500万美元。卢旺达问题国际法庭将成为下一代反恐调查员的学术和智力之家。卢旺达问题国际法庭将拥有一支由高级和初级C/T调查员组成的优秀教员队伍，他们将领导为履行RM-06-002号文件规定的关键职能而开发的资源。高级教员将为卢旺达问题国际法庭提供领导和地位，并担任初级教员和国际卢旺达问题国际法庭实习生的导师。被称为欧文研究员的初级教员将得到CUMC基金(450,000美元/年)的支持，并将与资深教员合作开发新的方法，以打破多学科和跨学科(M&L)C/T研究的障碍。欧文学者将成为CUMC开展M&L研究的典范，研究所提供的资源，包括在生物医学信息学、生物统计学和临床试验设计、生物伦理学、监管问题、以患者为中心的研究和核心资源方面的杰出支持和研究，将使我们能够推动这些变化。欧文研究员以及卢旺达问题国际法庭颁发的试点和合作研究补助金(每年70万美元)将由中央协委会提供支助。国际卢旺达问题国际法庭将拥有35,000平方英尺的空间，其中包括CUMC新建的6,000平方英尺住院/门诊研究空间(300万美元)，2,200平方英尺的临床导向研究教育中心(100万美元)，它将是我们的实习生和教职员工的家，以及一个新的校外研究中心，以支持以社区为基础的C/T研究和教育(100万美元)。我们创建了一个整合的教育项目，其中包括一个新的多学科患者导向研究硕士学位，一个新的K12学者在M&L研究方面的指导研究项目，以及一个开创性的以患者为中心的研究博士项目。将定期跟踪和评估CTSA的所有活动。儿科和基于社区的G/T研究将受到特别关注。卢旺达问题国际法庭和CTSA将打破阻碍新知识从法庭转移到床边和社区的障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Columbia University Medical Center's (CUMC) CTSA program will transform the culture of clinical and translational (C/T) research so that we can develop and retain an outstanding cadre of senior faculty to lead the next generation of C/T investigators. With outstanding support from the CUMC - Herbert Irving Endowment, which will increase from its present level of $15 million to $25 million dollars, we will accomplish our goal by creating the Irving Institute for Clinical and Translational Research (ifCTR). The IICTR will be the academic and intellectual home for the next generation of C/T investigators. The IICTR will have an outstanding faculty of senior and junior C/T investigators who will lead Resources developed to carry out the Key Functions defined in RM-06-002. The senior faculty will provide leadership and stature for the IICTR, and serve as mentors for both the junior faculty and IICTR trainees. The junior faculty, called Irving Fellows, will be supported by CUMC funds ($450,000/y) and will work with senior faculty to develop novel approaches to breaking down the barriers to multi- and interdisciplinary (M&l) C/T research. The Irving Scholars will be role models for the way M&l research should be conducted at CUMC, and the Resources provided by IICTR, including outstanding support and research in biomedical informatics, biostatistjcal and clincal trial design, bioethics, regulatory issues, patient oriented research, and core resources, will allow us actuate those changes. The Irving Fellows will be supported by CUMC as will pilot and collaborative research grants awarded by the IICTR ($700,000/yr). The IICTR will have 35,000 sq ft of space, including 6,000 sq ft of newly constructed space for inpatient/outpatient research at CUMC ($3 million), 2,200 sq ft of new space for the Center for Clinically Oriented Research Education ($1 million) that will be a home for our trainees and faculty, and a new off-campus research center to support community-based C/T research and education ($1 million). We have created an integrated eductional program that includes a new multidisciplinary patient oriented research (MPQR) Master's degree, a novel K12 Scholars Mentored Research Program in M&l research, and a pioneering MPOR PhD program. All CTSA activities will be tracked and evaluated regularly. Pediatfic and community-based G/T research will receive special attention. The IICTR and CTSA will break down the barriers impeding movement of new knowledge from the bench to the bedside and community.