Pediatric Center for Gene Expression and Development

本申请是为了继续资助我们的儿童健康研究事业发展奖 (CHRCDA)，它已经建立了一个独特的卓越中心，以加强基础和临床 儿科研究培训，重点是分子和细胞生物学以及临床科学。这是 第三次续签这笔赠款。我们的CHRCDA已经资助了我们机构的32名学者，其中许多人 成为学术儿科领域的全国领导者。我们的学者总共发表了约644篇论文和 获得了5000多万美元的赠款资金(包括28名R01的S)。该中心加强学术研究 年轻儿科教师的职业发展，提供导师和核心设施，旨在提高 对儿科医生进行的学术生涯所需的培训。该中心整合到创新 已建立的研究培训方案，包括Procter学者方案和NIH资助的大量资金 研究项目。该计划确定并招募有前途的年轻儿科教员，他们完成了2- 在由资深科学家导师组成的CHRCDA计划内加强研究的3年计划 他们共同关注分子细胞生物学、分子医学或临床科学。职业生涯 发展包括：1)中心工作人员调查人员的个人指导；2)正式和非正式培训 分子遗传学、发育生物学、临床研究、流行病学和转化研究； 3)核心研究要素，优先培训不同的研究方法，包括分子 生物学、免疫学、基因组学和转基因/基因靶向模型。目前的提案已经吸引了 共同在儿童医院和儿童医院建立了在发展科学方面卓有成效的研究人员 辛辛那提大学医学院。为实现PUR培训目标，建议成立一个由四个部分组成的中心： 1)在分子和细胞应用方面有共同兴趣和专业知识的中心工作人员 哺乳动物发育、分子医学和临床研究中的生物学和信息学技术 研究是儿科医生-学者的主要导师。2)行政核心确定招募人员 并监督儿科医生-学者的全面培训。核心为国家招聘提供支持 在地方和国家两级作出努力，优先招募少数群体。3)研究核心促进 分子和细胞生物学、临床研究/流行病学和统计学在研究中的应用 儿科医生-学者项目。4)研究资助提供儿科医生-学者研究 资金和指导，为期2-3年。这项个人指导计划和 当代分子、细胞、发育生物学和临床科学方面的高级培训 提高我们的物理学家的培训和研究效率，因为他们开始具有很高的生产力 儿科科学领域的学术生涯。

This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with focus on molecular and cellular biology and clinical sciences. This is the third renewal of this grant. Our CHRCDA has supported 32 scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our scholars have published ~644 papers and obtained over $50 million in grant dollars of funding (including 28 R01's). The Center enhances academic career development of young pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into innovative established programs for research trainmg including the Procter Scholar Program and extensive NIH funded research programs. The program identifies and recruits promising young pediatric faculty who complete a 2- 3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics, developmental biology, clinical research, epidemiology, and translational research; and 3) Core research elements which prioritizes training in diverse research approaches including molecular biology, immunology, genomics and transgenic/gene targeting models. The present proposal has drawn together established investigators with exceljence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet pur training goals, a four-part Center is proposed: 1) Center staff investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the pediatrician-scholars. 2) Administrative Core identifies recruits and monitors the overall training of pediatrician-scholars. The Core provides support for national recruitment efforts, at local and national levels and prioritizes minority recruitment. 3) Research Cores facilitate the application of molecular and cellular biology, clinical research/epidemiology and statistics to the research programs of pediatrician-scholars. 4) Research support grants provide the pediatrician-scholar research funds and mentorship for a period of 2-3 years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology, and clinical sciences enhances the training and research productivity of our physian-scholars as they begin highly productive academic careers in pediatric science.