Immunology Physician Scientist Training Grant

描述(由申请人提供)：这是NIH T32机构培训补助金的竞争性续签申请，用于在贝勒医学院继续新的培训计划，重点是培训医生作为免疫学学科的研究人员。最初的资金支持了6名学员，其中100%(3/3)的毕业学员获得了终身教职，83%的学员是女性，50%(3)的学员是URM。学员是从贝勒ACGME/RRC批准的过敏和免疫学以及风湿学培训计划的一大批优秀申请者中招募和挑选出来的。要求每年续设四个博士后实习生职位。学员被竞争性地挑选出来，每年被任命参加T32培训计划，接受两到三年的严格科学培训。根据他们在研究和教学方面的卓越表现，18名终身教职员工被精心挑选出来担任导师。学员参加研究生院的课程，贝勒的NIH K30支持临床研究中的内科科学家课程，以获得基础科学和免疫学、临床研究的原则和研究的道德行为方面的可靠知识。受训者将在假设驱动的研究、手稿的准备和出版、在全国会议上的陈述、赠款提案的准备、教学和指导的技能以及学术生涯发展方面得到全面的指导。导师来自贝勒多学科炎症生物学中心、NIH/NIAID德克萨斯医学中心哮喘和过敏性疾病合作研究中心以及HHMI翻译生物学和分子医学研究生项目的40多名教职员工，HHMI翻译生物学和分子医学研究生项目为研究人员提供高度互动的关键群体，学员包括研究生、医学生、博士后、MD博士后和MD/博士后。导师提供以下培训机会：细胞因子结构和功能、趋化因子生物学、黏附分子、信号转导和信号终止、基因激活、分子遗传学、组织重塑、细胞免疫学和免疫调节、小鼠炎症、感染和免疫模型、免疫介导性疾病的病理生物学、流行病学有效工具的设计以及临床试验结果分析。该培训计划的目标是继续培养免疫学内科科学家，他们将成为未来的学术带头人。

DESCRIPTION (provided by applicant): This is a competitive renewal application for a NIH T32 institutional training grant for continuation of a new training program at Baylor College of Medicine focused on the training of physicians as investigators in the discipline of immunology. Initial funding has supported 6 trainees, of which 100% (3/3) of graduating trainees have taken tenure track academic positions, 83% are women, and 50% (3) of trainees are URM. Trainees are recruited and selected from a large pool of outstanding applicants to Baylor's ACGME/RRC approved training programs in allergy and immunology and in rheumatology. Continuation of four postdoctoral trainee positions annually is requested. Trainees are competitively selected for appointed to the T32 training program each year for two to three years of rigorous scientific training. Eighteen tenure track faculty have been carefully selected to serve as mentors, based on their excellence in research and teaching. Trainees enroll in graduate school courses and Baylor's NIH K30 supported physician scientist curriculum in clinical investigation to acquire a sound fund of knowledge in basic science and immunology, the principles of conducting clinical research, and the ethical conduct of research. Trainees will be comprehensively mentored in hypothesis driven research, preparation and publication of manuscripts, presentations at national meetings, preparation of grant proposals, skills for teaching and mentoring, and academic career development. The mentors are selected from over 40 faculty within Baylor's multidisciplinary Biology of Inflammation Center, NIH/NIAID Texas Medical Center Asthma and Allergic Diseases Cooperative Research Center, and HHMI Translational Biology and Molecular Medicine graduate program,, which provides a highly interactive critical mass of investigators with diverse trainees comprised of graduate students, medical students, PhD postdocs, MD postdocs, and MD/PhD postdocs. Mentors provide training opportunities in cytokine structure and function, chemokine biology, adhesion molecules, signal transduction and termination of signaling, gene activation, molecular genetics, tissue remodeling, cellular immunology and immunoregulation, murine models of inflammation, infection and immunity, the pathobiology of immune-mediated diseases, design of valid tools for epidemiology, and clinical trial outcome analysis. The goal of this training program is to continue to develop immunology physician-scientists who will serve as future academic leaders.