Northeast Biodefense Center

东北生物防御中心（NBC）是一个由28个学术和研究机构（其中许多在大纽约市区彼此靠近）和13个美国政府和国际组织的350多名研究人员组成的联盟。在过去的5年里，NBC的调查人员已经证明了他们致力于跨学科和机构界限，在研究和培训计划，重点是生物防御和新出现的传染病以及应急准备。生产力的证据包括超过160篇出版物、15项发明披露、13项专利申请和5项产品开发许可。此次更新将包括42名研究人员和32个研究项目，分为6个科学主题领域：被动免疫治疗（主席：阿图罗·卡萨德瓦尔，爱因斯坦）;疫苗（主席：John Rose，耶鲁大学）;诊断和病原体发现（主席：Ian Lipkin，哥伦比亚）;治疗学（主持人：查尔斯·赖斯、洛克菲勒和霍华德·舒曼，哥伦比亚）;先天免疫（主持人：大卫·利维，纽约大学和阿道夫·加西亚-萨斯特雷，西奈半岛）和微生物致病（主持人：豪尔赫·E. Galan，Yale，and Jorge Benach，Stony Book）.生物技术和制药合作者在诊断和病原体发现（Agilent，Akonni，Cepheid，Xynostics，454 Life Sciences），治疗（Prosetta，Snowdon）和被动免疫治疗（Regeneron）主题中有代表。这些产业联系不仅提供了知识资本和资源，而且还提供了一条将发现从NBC实验室转移到更大的竞技场的道路，在那里它们可以为人类健康和福利做出贡献。额外的优势来自于与国家和国际公共卫生机构的关系，这些机构提供了获得见解和临床材料（例如诊断样本和PBMC）的独特途径，从而实现了无法以其他方式进行的工作。核心设施将包括蛋白质表达，动物模型和蛋白质组学。我们还将投资于发展项目（创新试点项目）和职业发展和培训计划，包括个人和团体职业发展奖励。作为公共卫生学院和州卫生部的一个中心，NBC对应急准备有着坚定的承诺和实际的理解。 战略管理计划（I Lipkin） 战略管理描述：东北生物防御中心是生物防御和新兴传染病研究的区域卓越中心，代表纽约、新泽西、康涅狄格、波多黎各和维尔京群岛30多个机构的350多名研究人员。行政核心的使命是通过为研究和职业发展颁发奖项、支持核心设施以及通过会议和电子媒体促进沟通和合作，促进生物防御方面的研究和培训方案。核心有三个站点，一个在哥伦比亚大学，那里的主任和首席研究员（利普金），副主任（黛安麦克法登）协调科学，财政和沟通方面的计划，第二个地点在沃兹沃斯中心的纽约州卫生部，沃兹沃斯中心联络员（Harry Taber）和公共卫生联络员（Lawrence Sturman）协调发展项目和职业发展计划以及应急响应计划，第三个在阿尔伯特·爱因斯坦医学院，副主任（Arturo Casadevall）与主任密切合作，协调中心并监测动物，表达和蛋白质组学核心。行政核心向一个指导委员会报告，该委员会由来自以下牵头机构的代表组成：阿尔伯特·爱因斯坦医学院、哥伦比亚大学、康奈尔大学、蒙大拿大学。西奈医学院、纽约大学、洛克菲勒大学、纽约州立大学斯托尼布鲁克、新泽西医学和牙科大学、沃兹沃斯中心和耶鲁大学。行政核心对全国广播公司的业绩进行年度审查，考虑到出版物、发明、提供和参加的会议和培训课程、在生物防御研究方面征聘和/或培训的科学家、促进区域环境教育中心内部和之间的合作以及科学咨询委员会和全国广播公司成员的评价等指标。每两年，在与NIAID计划工作人员协商后，核心聘请外部实体对中心绩效进行正式的独立评估。

DESCRIPTION (provided by applicant): The Northeast Biodefense Center (NBC) is a consortium of >350 investigators in 28 academic and research institutions (many of them in close proximity to one another in the greater NYC metro area), and 13 US based governmental and international organizations. Over the past 5 years, NBC investigators have demonstrated their commitment to working together across disciplines and institutional boundaries in research and training programs focused on biodefense and emerging infectious diseases as well as emergency preparedness. Evidence of productivity includes >160 publications, 15 invention disclosures, 13 patent applications and 5 licenses for product development. This renewal will comprise 42 investigators and 32 research projects organized into 6 scientific theme areas: Passive Immunotherapeutics (chair: Arturo Casadevall, Einstein); Vaccines (chair: John Rose, Yale); Diagnostics and Pathogen Discovery (chair: Ian Lipkin, Columbia); Therapeutics (chairs: Charles Rice, Rockefeller and Howard Shuman, Columbia,); Innate Immunity (chairs: David Levy, NYU, and Adolfo Garcia-Sastre, Sinai), and Microbial Pathogenesis (chairs: Jorge E. Galan, Yale, and Jorge Benach, Stony Book). Biotechnology and pharmaceutical collaborators are represented in the Diagnostics and Pathogen Discovery (Agilent, Akonni, Cepheid, Xynostics, 454 Life Sciences), Therapeutics (Prosetta, Snowdon), and Passive Immunotherapeutics (Regeneron) themes. These industrial links provide not only intellectual capital and resources but also a path for moving discoveries from NBC laboratories to a larger arena where they can contribute to human health and welfare. Additional strength derives from relationships with national and international public health agencies that provide unique access to insights and clinical materials (such as diagnostic samples and PBMC) that enable work that could not otherwise be pursuec. Core facilities will include Protein Expression, Animal Models, and Proteomics. We will also invest in Developmental Projects (innovative pilot projects) and in Career Development and Training Programs that include individual and group career development awards. As a Center based in a School of Public Health and a State Department of Health, the NBC has a firm commitment to and practical understanding of Emergency Preparedness. Strategic Management Plan (I Lipkin) STRATEGIC MANAGEMENT PLAN DESCRIPTION: The Northeast Biodefense Center is a Regional Center of Excellence for Research in Biodefense and Emerging Infectious Diseases that represents more than 350 investigators in more than 30 institutions in New York, New Jersey, Connecticut, Puerto Rico and the Virgin Islands. The mission of Administrative Core is to promote research and training programs in biodefense by distributing awards for research and career development, supporting core facilities, and facilitating communication and collaboration through meetings and electronic media. The Core has three sites, one at Columbia University, where the Director and Principal Investigator (Lipkin), and Associate Director (Diane McFadden) coordinate scientific, fiscal and communicative aspects of the program, a second site at the Wadsworth Center of the New York State Department of Health, where the Wadsworth Center Liaison (Harry Taber) and Public Health Liaison (Lawrence Sturman) coordinate the Developmental Projects and Career Development Programs as well as Emergency Response Planning, and a third at the Albert Einstein College of Medicine where the Deputy Director (Arturo Casadevall) works closely with the Director in coordinating the Center and monitors the Animal, Expression and Proteomics cores. The Administrative Core reports to a Steering Committee comprised of representatives from the lead institutions: the Albert Einstein College of Medicine, Columbia University, Cornell University, Mt. Sinai School of Medicine, New York University, The Rockefeller University, SUNY Stony Brook, University of Medicine and Dentistry of New Jersey, Wadsworth Center and Yale University. The Administrative Core pursues an annual review of NBC performance considering such metrics as publications, inventions, meetings and training course offered and attended, scientists recruited and/or trained in biodefense research, intra and inter-RCE collaborations fostered, and Scientific Advisory Board and NBC member evaluations. Every two years, in consultation with NIAID program staff, the Core engages an outside entity for a formal independent assessment of center performance.