African Descent And Glaucoma Evaluation Study (ADAGES)

描述(申请人提供)：非洲人后裔(AD)发生青光眼的可能性是欧洲人后裔(ED)的5倍，是AD患者失明的主要原因。非洲裔青光眼评估研究(ADAGES)是第一项前瞻性设计的多中心纵向研究，跟踪了一组非洲裔青光眼患者在视觉功能、视神经结构、风险评估和临床结果方面的各种指标。目的：确定非洲人后裔和欧洲人后裔之间青光眼发病和进展速度差异的原因，并确定这些差异是否可用于优化青光眼检测和监测进展的算法。目的：量化来自两个祖先群体的青光眼患者在视觉功能和视网膜结构方面的差异。结合结构和功能措施的信息，通过建立预测和风险因素的模型，改善进行性青光眼的诊断和随访，包括自我报告的种族和基因决定的祖先。参与者：364名健康人(218名AD)和860名患有青光眼或有青光眼风险的患者(693名AD)已完成基线测试，并正在接受跟踪调查。方法：每年对患者的眼睛进行为期5年的标准临床视野检查，以及两项特定功能的检查。将使用立体眼底照相和三种视网膜成像设备对视神经结构进行定性评估。重要性：在这项研究的结论中，从业者应该能够理解这两个祖先群体在视觉功能和视神经结构方面的任何差异，以及在解释这项研究中评估的常规和有希望的新程序的结果时如何解释这些差异。更好地记录青光眼变化的幅度和速度将有助于临床医生确定是否应该以及如何积极地治疗患者。人们将更好地了解血统和其他危险因素对青光眼发生和发展的重要性。

DESCRIPTION (provided by applicant): Glaucoma is 5 times more likely to occur in persons of African descent (AD) than in those of European descent (ED) and is the leading cause of blindness in AD individuals. The African Descent And Glaucoma Evaluation Study (ADAGES) is the first prospectively designed multi-center, longitudinal study to follow a well-characterized cohort of glaucoma patients of African Descent on a variety of measures of visual function, optic nerve structure, risk assessment, and clinical results. Purpose: To identify what factors account for the differences in glaucoma onset and rate of progression found between individuals of African descent and those of European descent and to determine whether accounting for these differences can be used to optimize algorithms for detection of glaucoma and for monitoring progression. Aims: To quantify differences in visual function and structure of the retina in glaucomatous individuals from the two ancestry groups. To combine information from structural and functional measures improving both diagnosis and follow-up of progressive glaucoma using modeling of predictive and risk factors, including self-reported race versus genetically determined ancestry. Participants: 364 healthy individuals (218 AD) and 860 patients (693 AD) with or at risk for glaucoma have completed baseline testing and are being followed. Methods: Patient eyes will be followed with annual testing for 5 additional years on standard clinical perimetry, and two function-specific tests. Optic nerve structure will be qualitatively evaluated with stereoscopic fundus photography and quantitatively using three retinal imaging devices. Importance: At the conclusion of this study, practitioners should be able to understand any differences in visual function and optic nerve structure between the two ancestry groups, and how to account for them when interpreting the results from both the routine and promising new procedures evaluated in this study. Better documentation of the magnitude and rate of glaucomatous changes will assist clinicians in determining whether and how aggressively patients should be treated. A greater understanding of the importance of ancestry and other risk factors for development and progression of glaucoma will result.