AAOS/ORS The Physis: Fundamental Knowledge to a Fantastic Future Through Research - 2018 Research Symposium

项目概要/摘要： 虽然骨骺板或生长板的结构已被组织学和放射学很好地描述， 但它的生理学仍然是个谜。调查人员已经探测了生长骨骺板，并确定了它的组成， 细胞外基质，胶原蛋白，某些生长因子的存在，并表征了组织形态计量学 它的细胞。然而，这些不同的实体在正常情况下以及在疾病面前如何相互作用尚不清楚。目前， 外科医生采用技术来减缓生长，并使用植入物来控制生长以矫正畸形;但是， 这些干预背后的机制是难以捉摸的。基本概念，如什么刺激增长和如何刺激增长， 目前还不清楚，这仍然是小儿骨科的圣杯。这个话题很及时， 外科干预趋向于微创治疗。通过定义机制， 基质、细胞和生长因子相互作用，可以开发药理学和外科手术干预。在 此外，肥胖儿童患肌肉骨骼骨骺疾病的比例过高。为 肥胖症在我们的儿科人群中肆虐，更多的儿童将遭受体格检查的后果。 疾病儿科患者将受益于对生长骨骺板更深入的了解，但也有好处， 科学界也是如此。了解内分泌级联在生长骨骺板上的作用， 深入了解儿童以外的软骨疾病，如骨关节炎和炎性关节炎。为了 开始，以进一步了解的physis和发展的治疗，我们已经制定了一个科学的 研讨会，让专家在基础科学和临床医学讨论目前的知识， 生长板，各种刺激对其结构的影响，并设计新的治疗方法， 紊乱本次研讨会将包括当前文献的摘要，原始研究报告， 在为期两天的互动论坛上进行公开和有针对性的讨论。专题讨论会的内容和结论 然后将通过在相关骨科杂志上发表向公众传播和提供。

Project Summary/Abstract: While the structure of the physis, or growth plate, has been well described by histology and radiologic measures, its physiology remains a mystery. Investigators have probed the physis and defined its makeup of extracellular matrix, collagen, the presence of certain growth factors, and characterized the histomorphometry of its cells. Yet how these different entities interact normally and in the face of disease is not known. Currently, surgeons employ techniques to slow growth and use implants to harness growth to correct deformity; but the mechanisms behind these interventions are elusive. Basic concepts such as what stimulates growth and how it can be harnessed is unknown; this remains the holy grail of pediatric orthopaedics. This topic is timely as surgical intervention is trending toward minimally invasive treatments. By defining the mechanisms by which the matrix, cells, and growth factors interact, pharmacologic and surgical interventions can be developed. In addition, a disproportionate share of musculoskeletal physeal diseases are found in obese children. As the obesity epidemic rages in our pediatric population, more children will suffer the consequences of physeal diseases. Pediatric patients will benefit from a deeper knowledge of the physis, but there are benefits to the larger scientific community as well. Understanding the endocrine cascade that works on the physis could give insights into cartilage disease beyond children, such as osteoarthritis and inflammatory arthritis. In order to begin to further our understanding of the physis and develop treatments, we have developed a scientific symposium to allow experts in both basic science and clinical medicine to discuss current knowledge about the growth plate, the effects of various stimuli on its structure, and to design novel treatments for physeal disorders. This symposium will include summaries of the current literature, original research presentations, and open and directed discussions over a two day interactive forum. The content and findings of the symposium will then be disseminated and available to the public through publication in a relevant orthopaedic journal.