Training Program in Developmental and Stem Cell Biology

 描述（由申请人提供）：发育和干细胞生物学培训计划的目标，本申请正在寻求持续的支持，是为来自不同背景的博士前个人提供科学和学术培训，以追求调查事业，并成为生物医学科学的未来领导者。该培训计划是由威尔康奈尔医学院和斯隆-凯特琳研究所共同管理的威尔康奈尔医学科学研究生院计划的一个组成部分，但又是其独特的一部分。该计划是跨学科的，并结合了发育和干细胞生物学的研究计划，从其九个研究计划中的六个，包括细胞和发育生物学，生物化学与结构生物学，分子生物学，神经科学，药理学，生理学，生物物理学和系统生物学。培训计划包括来自两个机构的46名教师，他们在学术研究和博士前和博士后学生培训方面具有丰富的集体经验。培训计划的研究兴趣由以下五个领域代表：发育遗传学，组织和器官的模式，干细胞，发育中的信号传导，以及人类发育和疾病。符合条件的学生由项目主任，联合主任和执行委员会根据他们的卓越承诺选择。该培训计划包括一个核心课程的课程和三个实验室轮换在第一年，两个签名课程，“发育生物学原理”和“干细胞”，以及辅导拨款写作课程，为ACE做准备（入学考试）在第二年，和期刊文章为基础的焦点小组在组织生物学和发展，并参加研究生研究研讨会在第二年至第五年。在第三和第四年的培训期间，挑选合格的受训人员领取津贴和学费支助。受训人员由项目主任指导，他们参加专门的培训项目活动，包括特邀演讲者的研讨会，研究进展研讨会，发育生物学和干细胞生物学研讨会和专题讨论会。 自4年前第一个资助期开始以来，已选出11名博士前学员，其中4人是代表性不足的少数民族。第一批学生在去年毕业，他们目前是博士后研究员或NIH研究员。我们已经能够选择优秀的学生，共28个出版物，其中14个是第一作者的手稿，53海报和21个口头报告的学生给出说明。从事发育和干细胞生物学培训计划的教师和学生人数在过去十年中稳步增加。目前，它包括46名教师导师和134名（2009年为54名学生）符合培训补助金条件的学生，其中20名（15%）是少数民族学生（2009年为7名学生，占13%）。为了继续为学生提供卓越的承诺培训，我们寻求在他们的第三和第四年的培训共六名研究生的支持。

 DESCRIPTION (provided by applicant): The objective of the Developmental and Stem Cell Biology Training Program, for which this application is seeking continued support, is to provide scientific and academic training to pre-doctoral individuals from diverse backgrounds to pursue investigative careers and become future leaders in the biomedical sciences. The Training program is an integral but distinct part of the umbrella Weill Cornell Graduate School of Medical Sciences Program, which is jointly administered by the Weill Cornell Medical College and the Sloan-Kettering Institute. The program is inter-disciplinary and incorporates research programs in Developmental and Stem Cell Biology from six out of its nine Programs of Study, including Cell and Developmental Biology, Biochemistry & Structural Biology, Molecular Biology, Neurosciences, Pharmacology, and Physiology, Biophysics, & Systems Biology. The Training Program includes 46 faculty members from both institutions with strong collective experience in academic research and training of pre- and post-doctoral students. The research interests in the Training Program are represented by the following five areas: Developmental Genetics, Patterning of Tissues and Organs, Stems Cells, Signaling in Development, and Human Development and Disease. Eligible students are selected by the Program Director, the co-Director and the Executive Committee, based on their promise of excellence. The Training program includes a core curriculum of courses and three laboratory rotations in year-1, two signature courses, "Principles of Developmental Biology" and "Stem Cells", and a tutored grant writing course in preparation for the ACE (Admission to Candidacy Exam) during year-2, and journal article-based Focus Groups in Tissue Biology and Development, and participation in Graduate Student Research Seminars during years 2 to 5. Eligible trainees are selected for stipend and tuition support during years 3 and 4 of training. Trainees are mentored by the Program Director, and they attend specialized Training Program events, including seminars by invited speakers, Research-in-Progress seminars, and Developmental Biology and Stem Cell Biology workshops and symposia. Since the start of the first funding period 4 years ago, 11 pre-doctoral trainees have been selected, 4 of who are underrepresented minorities. The first group of students graduated during the past year; they are presently post-doctoral fellows or NIH fellows. We have been able to select outstanding students, as illustrated by a total 28 publications, 14 of which are first-author manuscripts, and 53 posters and 21 oral presentations given by the students. The number of faculty and students engaged in the Developmental and Stem Cell Biology Training Program has steadily increased over the past decade. Presently, it includes 46 faculty mentors and 134 (up from 54 students in 2009) training grant- eligible students, 20 of who (15%) are minority students (up from 7 students in 2009; 13%). To continue with providing training of students with a commitment to excellence, we seek support for a total of six graduate students in their third and fourth year of training.