Impact of Marijuana Legalization: Comparison of Two Longitudinal Twin Cohorts

项目摘要 我们建议研究娱乐性大麻合法化对大麻使用发展的影响 和大麻使用障碍、酒精、尼古丁和其他物质使用和使用障碍，以及相关的 心理调适和精神病理学。为了做到这一点，我们将比较两个人群的结果 从青春期开始纵向跟踪超过15年的双胞胎样本。儿童的年龄范围 在他们的后续评估中，样本将是23-39个，因此，我们将能够检查 关于成年早期到中期家庭形成、工作投入和成人角色功能的合法化 实现了。我们将在这些样本中获得额外的数据波动，以检查 大麻、酒精和其他物质使用和使用障碍以及相关疾病的合法化 心理调适和精神病理学。其中一个样本来自科罗拉多州，那里的成年人合法化 2014年娱乐性大麻的使用，现在有广泛的商业大麻可供 消费者。另一个样本来自明尼苏达州，该州在2014年将医用大麻合法化，要求非常严格 限制进入，并且没有娱乐合法化。连同我们详细的先前纵向数据， 新的评估，药物使用合法化后，精神病理学和心理社会功能 基于5000个人口的成年双胞胎将提供独特而有力的数据来了解 娱乐性大麻合法化和大麻使用取得了各种各样的重要成果。此外， 娱乐性大麻合法化的影响不太可能在所有人口中都是一致的。相反，有些人 个人将面临更高的风险遭受RML的负面后果，如增加使用和 依赖。利用这项研究的纵向和孪生结构，我们将能够确定 合法化前行为风险和心理社会功能的个体差异对戒毒效果的影响 娱乐性大麻合法化。

PROJECT ABSTRACT We propose to examine the impact of recreational marijuana legalization on the development of marijuana use and marijuana use disorders, alcohol, nicotine, and other substance use and use disorders, and associated psychological adjustment and psychopathology. To do this, we will compare outcomes in two population based twin samples that have been followed longitudinally for over 15 years since adolescence. The age ranges of the samples at will be 23-39 at their follow-up assessment, thus, we will be able to examine the impact of legalization on early- to mid-adulthood functioning of family formation, work engagement, and adult role fulfillment. We will obtain additional waves of data in these samples in order to examine the effect of legalization on rates of marijuana, alcohol and other substance use and use disorders as well as associated psychological adjustment and psychopathology. One of these samples is from Colorado, which legalized adult recreational marijuana use in 2014 and now has widespread commercial marijuana readily available to consumers. The other sample is from Minnesota, which in 2014 legalized medical marijuana, with very strict limits on access, and has no recreational legalization. Together with our detailed prior longitudinal data, the new assessments, post-legalization of substance use, psychopathology, and psychosocial functioning in over 5000 population-based adult twins will provide unique and powerful data to understand the impact of recreational marijuana legalization and marijuana use on a wide variety of important outcomes. Furthermore, the effect of recreational marijuana legalization is unlikely to be uniform across the population. Rather, some individuals will be at higher risk to suffer negative consequences of RML, such as increased use and dependence. Leveraging the longitudinal and twin structure of the study, we will be able to determine the influence of pre-legalization individual differences in behavioral risk and psychosocial function on the effect of recreational marijuana legalization.